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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Coq7tm2Hek
targeted mutation 2, Siegfried Hekimi
MGI:5532527
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Coq7tm2Hek/Coq7tm2Hek involves: 129S6/SvEvTac * C57BL/6NTac MGI:5532532
cn2
 		Coq7tm2Hek/Coq7tm2Hek involves: 129S6/SvEvTac * C57BL/6NTac MGI:5532533
cn3
 		Coq7tm1Hek/Coq7tm2Hek
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ 		involves: 129S6/SvEvTac * C57BL/6NTac MGI:5532534


Genotype
MGI:5532532
hm1
Allelic
Composition		 Coq7tm2Hek/Coq7tm2Hek
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Coq7tm2Hek mutation (0 available); any Coq7 mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:202240 )
• mice develop normally and are indistinguishable form wild-type mice




Genotype
MGI:5532533
cn2
Allelic
Composition		 Coq7tm2Hek/Coq7tm2Hek
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Coq7tm2Hek mutation (0 available); any Coq7 mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
cellular phenotype ( J:202240 )
N
• mouse embryonic fibroblasts transfected with a cre-expressing retrovirus exhibit normal viability, growth and morphology without the addition of exogenous ubiquinone
increased cell death ( J:202240 )
• after exposure to glycolytic inhibition by 2-deoxyl-D-glucose (2-DG) or culture in galactose medium with or without vitamin K2, mouse embryonic fibroblasts transfected with a cre-expressing retrovirus exhibit reduced viability compared with control cells
• however, exogenous ubiquinine rescues viability
abnormal respiratory electron transport chain ( J:202240 )
• mouse embryonic fibroblasts transfected with a cre-expressing retrovirus exhibit impaired respiratory chain function with reduced complex II and II+III activity compared with control cells
• however, cells exhibit normal complex I and III activity and ATP synthesis




Genotype
MGI:5532534
cn3
Allelic
Composition		 Coq7tm1Hek/Coq7tm2Hek
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Coq7tm1Hek mutation (0 available); any Coq7 mutation (29 available)
Coq7tm2Hek mutation (0 available); any Coq7 mutation (29 available)
Speer6-ps1Tg(Alb-cre)21Mgn mutation (6 available); any Speer6-ps1 mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:202240 )
N
• mice exhibit normal mortality

liver/biliary system
liver/biliary system phenotype ( J:202240 )
N
• mice exhibit normal liver morphology
abnormal liver physiology ( J:202240 )
• mild reduction in respiratory capacity in liver mitochondria
• however, a diet supplemented with dietary ubiquinine rescues respiratory chain function

cellular
abnormal respiratory electron transport chain ( J:202240 )
• mild reduction in respiratory capacity in liver mitochondria
• however, a diet supplemented with dietary ubiquinine rescues respiratory chain function




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory