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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tcratm1Mass
targeted mutation 1, Marc Schmidt-Supprian
MGI:5532653
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tcratm1Mass/Tcratm1Mass involves: C57BL/6 MGI:5532664
cn2
 		Tcratm1Cgn/Tcratm1Mass
Tg(Mx1-cre)1Cgn/0 		involves: C57BL/6 * CBA MGI:5532665
cn3
 		Tcratm1Mass/Tcra+
Tg(Nes-cre)Wme/0 		involves: C57BL/6 * CBA MGI:5532668
cn4
 		Tcratm1Mass/Tcra+
Tg(Cd4-cre)1Cwi/0 		involves: C57BL/6 * DBA/2 MGI:5532666


Genotype
MGI:5532664
hm1
Allelic
Composition		 Tcratm1Mass/Tcratm1Mass
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcratm1Mass mutation (0 available); any Tcra mutation (96 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system

immune system




Genotype
MGI:5532665
cn2
Allelic
Composition		 Tcratm1Cgn/Tcratm1Mass
Tg(Mx1-cre)1Cgn/0
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcratm1Cgn mutation (0 available); any Tcra mutation (96 available)
Tcratm1Mass mutation (0 available); any Tcra mutation (96 available)
Tg(Mx1-cre)1Cgn mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased T cell number ( J:201417 )
• uninduced mice exhibit an increase in tetramer+ T cells due to leaky cre expression
abnormal T cell physiology ( J:201417 )
• TCR-switched T cells treated with pIpC induce sterile inflammation in recipient mice possibly due to autoimmune activation
• however, recipient mice treated with galactosylceramide do not exhibit induction of NK T cell differentiation of TCR-switched tetramer+ T cells

hematopoietic system
increased T cell number ( J:201417 )
• uninduced mice exhibit an increase in tetramer+ T cells due to leaky cre expression
abnormal T cell physiology ( J:201417 )
• TCR-switched T cells treated with pIpC induce sterile inflammation in recipient mice possibly due to autoimmune activation
• however, recipient mice treated with galactosylceramide do not exhibit induction of NK T cell differentiation of TCR-switched tetramer+ T cells




Genotype
MGI:5532668
cn3
Allelic
Composition		 Tcratm1Mass/Tcra+
Tg(Nes-cre)Wme/0
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcratm1Mass mutation (0 available); any Tcra mutation (96 available)
Tg(Nes-cre)Wme mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased NK T cell number ( J:201417 )
• in the thymus and spleen

hematopoietic system
decreased NK T cell number ( J:201417 )
• in the thymus and spleen

endocrine/exocrine glands




Genotype
MGI:5532666
cn4
Allelic
Composition		 Tcratm1Mass/Tcra+
Tg(Cd4-cre)1Cwi/0
Genetic
Background		 involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcratm1Mass mutation (0 available); any Tcra mutation (96 available)
Tg(Cd4-cre)1Cwi mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal NK T cell morphology ( J:201417 )
• abnormal NK T cell maturation
increased NK T cell number ( J:201417 )
• 23 times more in the thymus
• 43 times more in the spleen
• in mice treated with galactosylceramide

hematopoietic system
abnormal NK T cell morphology ( J:201417 )
• abnormal NK T cell maturation
increased NK T cell number ( J:201417 )
• 23 times more in the thymus
• 43 times more in the spleen
• in mice treated with galactosylceramide




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
06/12/2024
MGI 6.13 		The Jackson Laboratory