Phenotypes associated with this allele

• Allele Symbol: Tg(ACTB-Edn1)721Clou
• Allele Name: transgene insertion 721, David E Clouthier
• Allele ID: MGI:5538246
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Tg(ACTB-Edn1)721Clou/0 E2f1^Tg(Wnt1-cre)2Sor/E2f1^+	involves: 129S4/SvJae * C3H * C57BL/6	MGI:5754723
cn2	Myf5^tm3(cre)Sor/Myf5^+ Tg(ACTB-Edn1)721Clou/0	involves: 129S4/SvJaeSor * C57BL/6	MGI:5754730

Genotype
MGI:5754723

cn1

• Allelic Composition: Tg(ACTB-Edn1)721Clou/0; E2f1^{Tg(Wnt1-cre)2Sor}/E2f1⁺
• Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

craniofacial

basisphenoid bone hypoplasia ( J:221133 )

• basisphenoid bone is hypoplastic in the duplicated mandible

abnormal Meckel's cartilage morphology ( J:221133 )

• duplication of Meckel's cartilage in the duplicated mandible

abnormal temporal bone squamous part morphology ( J:221133 )

• the squamosal bone is deformed in the duplicated mandible

abnormal mandible morphology ( J:221133 )

• the duplicated mandible contains a duplicated Meckels cartilage, absent jugal and palatine bones, deformed squamosal bones, a hypoplastic basisphenoid bone and a palatal cleft

upper jaw to lower jaw transformation ( J:221133 )

• transformation of the maxilla into a mandible-like structure that is fused with the mandible

absent palatine bone ( J:221133 )

• palatine bone is absent in the duplicated mandible

absent zygomatic bone ( J:221133 )

• jugal bone is absent in the duplicated mandible

cleft palate ( J:221133 )

midline facial cleft ( J:221133 )

• mice exhibit a large mid-facial cleft

digestive/alimentary system

cleft palate ( J:221133 )

growth/size/body

cleft palate ( J:221133 )

midline facial cleft ( J:221133 )

• mice exhibit a large mid-facial cleft

skeleton

basisphenoid bone hypoplasia ( J:221133 )

• basisphenoid bone is hypoplastic in the duplicated mandible

abnormal Meckel's cartilage morphology ( J:221133 )

• duplication of Meckel's cartilage in the duplicated mandible

abnormal temporal bone squamous part morphology ( J:221133 )

• the squamosal bone is deformed in the duplicated mandible

abnormal mandible morphology ( J:221133 )

• the duplicated mandible contains a duplicated Meckels cartilage, absent jugal and palatine bones, deformed squamosal bones, a hypoplastic basisphenoid bone and a palatal cleft

upper jaw to lower jaw transformation ( J:221133 )

• transformation of the maxilla into a mandible-like structure that is fused with the mandible

absent palatine bone ( J:221133 )

• palatine bone is absent in the duplicated mandible

absent zygomatic bone ( J:221133 )

• jugal bone is absent in the duplicated mandible

Genotype
MGI:5754730

cn2

• Allelic Composition: Myf5^tm3(cre)Sor/Myf5⁺; Tg(ACTB-Edn1)721Clou/0
• Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

skeleton

abnormal costal cartilage morphology ( J:221133 )

• fusions between the first and second costal cartilages