Phenotypes associated with this allele

• Allele Symbol: Tg(ACTB-Edn1)1398Clou
• Allele Name: transgene insertion 1398, David E Clouthier
• Allele ID: MGI:5538247
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Tg(ACTB-Edn1)1398Clou/0 E2f1^Tg(Wnt1-cre)2Sor/E2f1^+	involves: 129S4/SvJae * C3H * C57BL/6	MGI:5754726
cn2	Myf5^tm3(cre)Sor/Myf5^+ Tg(ACTB-Edn1)1398Clou/0	involves: 129S4/SvJaeSor * C57BL/6	MGI:5754731

Genotype
MGI:5754726

cn1

• Allelic Composition: Tg(ACTB-Edn1)1398Clou/0; E2f1^{Tg(Wnt1-cre)2Sor}/E2f1⁺
• Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

craniofacial

temporal bone squamous part hypoplasia ( J:221133 )

• hypoplastic squamosal bone

abnormal mandibular angle morphology ( J:221133 )

• duplication of the angular process

absent mandibular coronoid process ( J:221133 )

• the coronoid process of the mandible is lost due to fusion of the mandible and the duplicated mandible

upper jaw to lower jaw transformation ( J:221133 )

• complete homeotic transformation of the upper jaw (maxilla and jugal bones) into a mandible-like structure, with duplicated angular and condylar processes

palatine bone hypoplasia ( J:221133 )

abnormal zygomatic bone morphology ( J:221133 )

• complete homeotic transformation of the upper jaw (maxilla and jugal bones) into a mandible-like structure, with duplicated angular and condylar processes

ectopic cranial bone ( J:221133 )

• an ectopic bone is present suggestive of duplicated gonial bone and/or part of the tympanic ring

abnormal incus morphology ( J:221133 )

• additional cartilage is present that appears to be duplication of the malleus and incus

abnormal malleus morphology ( J:221133 )

• additional cartilage is present that appears to be duplication of the malleus and incus

gonial bone hypoplasia ( J:221133 )

cleft palate ( J:221133 )

digestive/alimentary system

palatine bone hypoplasia ( J:221133 )

cleft palate ( J:221133 )

growth/size/body

palatine bone hypoplasia ( J:221133 )

cleft palate ( J:221133 )

hearing/vestibular/ear

abnormal incus morphology ( J:221133 )

• additional cartilage is present that appears to be duplication of the malleus and incus

abnormal malleus morphology ( J:221133 )

• additional cartilage is present that appears to be duplication of the malleus and incus

gonial bone hypoplasia ( J:221133 )

tympanic ring hypoplasia ( J:221133 )

• hypoplastic tympanic ring

skeleton

temporal bone squamous part hypoplasia ( J:221133 )

• hypoplastic squamosal bone

abnormal mandibular angle morphology ( J:221133 )

• duplication of the angular process

absent mandibular coronoid process ( J:221133 )

• the coronoid process of the mandible is lost due to fusion of the mandible and the duplicated mandible

upper jaw to lower jaw transformation ( J:221133 )

• complete homeotic transformation of the upper jaw (maxilla and jugal bones) into a mandible-like structure, with duplicated angular and condylar processes

palatine bone hypoplasia ( J:221133 )

abnormal zygomatic bone morphology ( J:221133 )

• complete homeotic transformation of the upper jaw (maxilla and jugal bones) into a mandible-like structure, with duplicated angular and condylar processes

ectopic cranial bone ( J:221133 )

• an ectopic bone is present suggestive of duplicated gonial bone and/or part of the tympanic ring

abnormal incus morphology ( J:221133 )

• additional cartilage is present that appears to be duplication of the malleus and incus

abnormal malleus morphology ( J:221133 )

• additional cartilage is present that appears to be duplication of the malleus and incus

gonial bone hypoplasia ( J:221133 )

Genotype
MGI:5754731

cn2

• Allelic Composition: Myf5^tm3(cre)Sor/Myf5⁺; Tg(ACTB-Edn1)1398Clou/0
• Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

skeleton

abnormal costal cartilage morphology ( J:221133 )

• fusions between the first and second costal cartilages, with varying other costal cartilage fusions at E18.5

rib fusion ( J:221133 )

• fusions between adjoining ribs