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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(ACTB-Edn1)1416Clou
transgene inssertion 1416, David E Clouthier
MGI:5538249
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Tg(ACTB-Edn1)1416Clou/0
E2f1Tg(Wnt1-cre)2Sor/E2f1+ 		involves: 129S4/SvJae * C3H * C57BL/6 MGI:5754729
cn2
 		Myf5tm3(cre)Sor/Myf5+
Tg(ACTB-Edn1)1416Clou/0 		involves: 129S4/SvJaeSor * C57BL/6 MGI:5754733


Genotype
MGI:5754729
cn1
Allelic
Composition		 Tg(ACTB-Edn1)1416Clou/0
E2f1Tg(Wnt1-cre)2Sor/E2f1+
Genetic
Background		 involves: 129S4/SvJae * C3H * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
E2f1Tg(Wnt1-cre)2Sor mutation (2 available); any E2f1 mutation (28 available)
Tg(ACTB-Edn1)1416Clou mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
abnormal Meckel's cartilage morphology ( J:221133 )
• duplication of the Meckel's cartilage
temporal bone squamous part hypoplasia ( J:221133 )
• hypoplastic squamosal bone
abnormal mandibular angle morphology ( J:221133 )
• the condylar and angular processes are duplicated
absent mandibular coronoid process ( J:221133 )
• loss of the coronoid process
upper jaw to lower jaw transformation ( J:221133 )
• transformation of the maxilla into a mandible-like structure
midline facial cleft ( J:221133 )
• 70% of mutants exhibit a large mid-facial cleft; cleft does not affect the transformation of the maxilla

growth/size/body
palatine bone hypoplasia ( J:221133 )
midline facial cleft ( J:221133 )
• 70% of mutants exhibit a large mid-facial cleft; cleft does not affect the transformation of the maxilla

hearing/vestibular/ear
tympanic ring hypoplasia ( J:221133 )
• hypoplastic tympanic ring

skeleton
abnormal Meckel's cartilage morphology ( J:221133 )
• duplication of the Meckel's cartilage
temporal bone squamous part hypoplasia ( J:221133 )
• hypoplastic squamosal bone
abnormal mandibular angle morphology ( J:221133 )
• the condylar and angular processes are duplicated
absent mandibular coronoid process ( J:221133 )
• loss of the coronoid process
upper jaw to lower jaw transformation ( J:221133 )
• transformation of the maxilla into a mandible-like structure
ectopic cartilage ( J:221133 )
• the middle ear is composed of a large piece of ectopic cartilage

digestive/alimentary system




Genotype
MGI:5754733
cn2
Allelic
Composition		 Myf5tm3(cre)Sor/Myf5+
Tg(ACTB-Edn1)1416Clou/0
Genetic
Background		 involves: 129S4/SvJaeSor * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myf5tm3(cre)Sor mutation (1 available); any Myf5 mutation (17 available)
Tg(ACTB-Edn1)1416Clou mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
upper jaw to lower jaw transformation ( J:221133 )
• one mutant exhibits partial homeotic transformation of the maxilla into a mandible

skeleton
upper jaw to lower jaw transformation ( J:221133 )
• one mutant exhibits partial homeotic transformation of the maxilla into a mandible
abnormal costal cartilage morphology ( J:221133 )
• fusions between the first and second costal cartilages, with varying other costal cartilage fusions at E18.5
rib fusion ( J:221133 )
• fusions between adjoining ribs




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory