About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(ACTB-Edn1)1416Clou
transgene inssertion 1416, David E Clouthier
MGI:5538249
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Tg(ACTB-Edn1)1416Clou/0
E2f1Tg(Wnt1-cre)2Sor/E2f1+ 		involves: 129S4/SvJae * C3H * C57BL/6 MGI:5754729
cn2
 		Myf5tm3(cre)Sor/Myf5+
Tg(ACTB-Edn1)1416Clou/0 		involves: 129S4/SvJaeSor * C57BL/6 MGI:5754733


Genotype
MGI:5754729
cn1
Allelic
Composition		 Tg(ACTB-Edn1)1416Clou/0
E2f1Tg(Wnt1-cre)2Sor/E2f1+
Genetic
Background		 involves: 129S4/SvJae * C3H * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
E2f1Tg(Wnt1-cre)2Sor mutation (2 available); any E2f1 mutation (28 available)
Tg(ACTB-Edn1)1416Clou mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
abnormal Meckel's cartilage morphology ( J:221133 )
• duplication of the Meckel's cartilage
temporal bone squamous part hypoplasia ( J:221133 )
• hypoplastic squamosal bone
abnormal mandibular angle morphology ( J:221133 )
• the condylar and angular processes are duplicated
absent mandibular coronoid process ( J:221133 )
• loss of the coronoid process
upper jaw to lower jaw transformation ( J:221133 )
• transformation of the maxilla into a mandible-like structure
midline facial cleft ( J:221133 )
• 70% of mutants exhibit a large mid-facial cleft; cleft does not affect the transformation of the maxilla

growth/size/body
palatine bone hypoplasia ( J:221133 )
midline facial cleft ( J:221133 )
• 70% of mutants exhibit a large mid-facial cleft; cleft does not affect the transformation of the maxilla

hearing/vestibular/ear
tympanic ring hypoplasia ( J:221133 )
• hypoplastic tympanic ring

skeleton
abnormal Meckel's cartilage morphology ( J:221133 )
• duplication of the Meckel's cartilage
temporal bone squamous part hypoplasia ( J:221133 )
• hypoplastic squamosal bone
abnormal mandibular angle morphology ( J:221133 )
• the condylar and angular processes are duplicated
absent mandibular coronoid process ( J:221133 )
• loss of the coronoid process
upper jaw to lower jaw transformation ( J:221133 )
• transformation of the maxilla into a mandible-like structure
ectopic cartilage ( J:221133 )
• the middle ear is composed of a large piece of ectopic cartilage

digestive/alimentary system




Genotype
MGI:5754733
cn2
Allelic
Composition		 Myf5tm3(cre)Sor/Myf5+
Tg(ACTB-Edn1)1416Clou/0
Genetic
Background		 involves: 129S4/SvJaeSor * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myf5tm3(cre)Sor mutation (1 available); any Myf5 mutation (17 available)
Tg(ACTB-Edn1)1416Clou mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
upper jaw to lower jaw transformation ( J:221133 )
• one mutant exhibits partial homeotic transformation of the maxilla into a mandible

skeleton
upper jaw to lower jaw transformation ( J:221133 )
• one mutant exhibits partial homeotic transformation of the maxilla into a mandible
abnormal costal cartilage morphology ( J:221133 )
• fusions between the first and second costal cartilages, with varying other costal cartilage fusions at E18.5
rib fusion ( J:221133 )
• fusions between adjoining ribs




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory