All Phenotypes Pms2<tm2(cre)Lisk> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Pms2^tm2(cre)Lisk
targeted mutation 2, Michael Liskay
MGI:5538273

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pms2^tm2(cre)Lisk/Pms2^tm2(cre)Lisk	Not Specified	MGI:5543245
cn2	Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺ Kras^tm4Tyj/Kras⁺ Pms2^tm2(cre)Lisk/Pms2^tm2(cre)Lisk	involves: 129S4/SvJae * 129S4/SvJaeSor	MGI:5543250
cn3	Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺ Pms2^tm2(cre)Lisk/Pms2^tm2(cre)Lisk	involves: 129S4/SvJaeSor	MGI:5543251

Allelic Composition	Pms2^tm2(cre)Lisk/Pms2^tm2(cre)Lisk
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pms2^tm2(cre)Lisk mutation (0 available); any Pms2 mutation (53 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:204653 )

• homozygotes show reduced lifespan with a half-life of 10 months

Allelic Composition	Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺ Kras^tm4Tyj/Kras⁺ Pms2^tm2(cre)Lisk/Pms2^tm2(cre)Lisk
Genetic Background	involves: 129S4/SvJae * 129S4/SvJaeSor

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^tm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (993 available)
Kras^tm4Tyj mutation (9 available); any Kras mutation (84 available)
Pms2^tm2(cre)Lisk mutation (0 available); any Pms2 mutation (53 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal mismatch repair ( J:204653 )

• numbers of stained spots in intestines is not increased compared to mice without the Kras allele, but size of stained patches increases suggesting sporadic cre activation of Kras which might have a selective advantage for mutant stem cells resulting in clonal expansion and crypt fission

neoplasm

increased lung tumor incidence ( J:204653 )

• animals become moribund at 5 weeks of age due to high lung tumor burden

cellular

abnormal mismatch repair ( J:204653 )

respiratory system

increased lung tumor incidence ( J:204653 )

• animals become moribund at 5 weeks of age due to high lung tumor burden

Allelic Composition	Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺ Pms2^tm2(cre)Lisk/Pms2^tm2(cre)Lisk
Genetic Background	involves: 129S4/SvJaeSor

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^tm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (993 available)
Pms2^tm2(cre)Lisk mutation (0 available); any Pms2 mutation (53 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal mismatch repair ( J:204653 )

• DNA mismatch repair (measured by cre reversion and activation of the lacZ reporter) is increased about 100 fold relative to mice heterozygous form the Pms2 allele

• average numbers of gastrointestinal tract spots (stained villi) in homozygous Pms2 mutants is 3300 compared to 26 in Pms2 heterozygotes

homeostasis/metabolism

abnormal mismatch repair ( J:204653 )

• DNA mismatch repair (measured by cre reversion and activation of the lacZ reporter) is increased about 100 fold relative to mice heterozygous form the Pms2 allele

• average numbers of gastrointestinal tract spots (stained villi) in homozygous Pms2 mutants is 3300 compared to 26 in Pms2 heterozygotes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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