All Phenotypes Lhcgr<tm1.1Pnara> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Lhcgr^tm1.1Pnara
targeted mutation 1.1, Prema Narayan
MGI:5538310

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Lhcgr^tm1.1Pnara/Lhcgr⁺	involves: 129S1/SvImJ * 129X1/SvJ * C57BL/6J	MGI:5538381

Allelic Composition	Lhcgr^tm1.1Pnara/Lhcgr⁺
Genetic Background	involves: 129S1/SvImJ * 129X1/SvJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lhcgr^tm1.1Pnara mutation (1 available); any Lhcgr mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:203295 )

N	• mice exhibit normal Sertoli cell development and sperm

enlarged prostate gland ( J:203295 )

• at 3 weeks

increased prostate gland weight ( J:203295 )

• from P10

enlarged seminal vesicle ( J:203295 )

• at 3 weeks

increased seminal vesicle weight ( J:203295 )

• from 3 weeks

abnormal adult Leydig cell differentiation ( J:203295 )

• precocious development of adult Leydig cells

increased Leydig cell number ( J:203295 )

• as early as 7 days, persisting through adulthood

decreased testis weight ( J:203295 )

• from P10

increased epididymis weight ( J:203295 )

• P10 to 3 weeks

early sexual maturation ( J:203295 )

• in male mice

homeostasis/metabolism

decreased circulating follicle stimulating hormone level ( J:203295 )

decreased circulating luteinizing hormone level ( J:203295 )

abnormal testosterone level ( J:203295 )

• increased in testes from P7

increased circulating testosterone level ( J:203295 )

• from 3 weeks

increased urine major urinary protein level ( J:203295 )

• at 15 days in male mice indicating precocious puberty

renal/urinary system

increased urine major urinary protein level ( J:203295 )

• at 15 days in male mice indicating precocious puberty

endocrine/exocrine glands

enlarged prostate gland ( J:203295 )

• at 3 weeks

increased prostate gland weight ( J:203295 )

• from P10

enlarged seminal vesicle ( J:203295 )

• at 3 weeks

increased seminal vesicle weight ( J:203295 )

• from 3 weeks

abnormal adult Leydig cell differentiation ( J:203295 )

• precocious development of adult Leydig cells

increased Leydig cell number ( J:203295 )

• as early as 7 days, persisting through adulthood

decreased testis weight ( J:203295 )

• from P10

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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