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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mecp2tm3Meg
targeted mutation 3, Michael E Greenberg
MGI:5538511
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
ot1
 		Mecp2tm3Meg/Y B6.129-Mecp2tm3Meg MGI:5538526


Genotype
MGI:5538526
ot1
Allelic
Composition		 Mecp2tm3Meg/Y
Genetic
Background		 B6.129-Mecp2tm3Meg
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecp2tm3Meg mutation (0 available); any Mecp2 mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
increased susceptibility to pharmacologically induced seizures ( J:204723 )
• mice treated with pentylenetetrazol (PTZ) exhibit earlier onset time and frequency of tonic-clonic seizures compared with wild-type mice
impaired coordination ( J:204723 )
• on a rotarod

nervous system
increased susceptibility to pharmacologically induced seizures ( J:204723 )
• mice treated with pentylenetetrazol (PTZ) exhibit earlier onset time and frequency of tonic-clonic seizures compared with wild-type mice

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
Rett syndrome DOID:1206 OMIM:312750
OMIM:613454
 J:204723




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory