Phenotypes associated with this allele

• Allele Symbol: Trim62^tm1Akil
• Allele Name: targeted mutation 1, Ann McNeill Killary
• Allele ID: MGI:5538538
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Trim62^tm1Akil/Trim62^tm1Akil	involves: 129S/SvEv * C57BL/6	MGI:5538540
ht2	Trim62^tm1Akil/Trim62^+	involves: 129S/SvEv * C57BL/6	MGI:5538541

Genotype
MGI:5538540

hm1

• Allelic Composition: Trim62^tm1Akil/Trim62^tm1Akil
• Genetic Background: involves: 129S/SvEv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

increased mammary adenocarcinoma incidence ( J:204336 )

mortality/aging

mortality/aging ( J:204336 )

N • mice exhibit normal survival

neoplasm

increased tumor incidence ( J:204336 )

• in 8 of 62 mice

increased lymphoma incidence ( J:204336 )

• low and high grade in multiple organ sites (liver, stomach, kidney and mammary gland)

increased adenocarcinoma incidence ( J:204336 )

• in the mammary, pancreatic, lung and liver

increased mammary adenocarcinoma incidence ( J:204336 )

increased liver adenocarcinoma incidence ( J:204336 )

increased lung adenocarcinoma incidence ( J:204336 )

increased squamous cell carcinoma incidence ( J:204336 )

• basaloid squamous carcinoma

increased sarcoma incidence ( J:204336 )

• low and high grade in multiple organ sites

integument

increased mammary adenocarcinoma incidence ( J:204336 )

liver/biliary system

increased liver adenocarcinoma incidence ( J:204336 )

respiratory system

increased lung adenocarcinoma incidence ( J:204336 )

Genotype
MGI:5538541

ht2

• Allelic Composition: Trim62^tm1Akil/Trim62⁺
• Genetic Background: involves: 129S/SvEv * C57BL/6

endocrine/exocrine glands

increased mammary adenocarcinoma incidence ( J:204336 )

mortality/aging

mortality/aging ( J:204336 )

N • mice exhibit normal survival

neoplasm

increased tumor incidence ( J:204336 )

• in 17 of 96 mice

increased hepatocellular carcinoma incidence ( J:204336 )

increased lymphoma incidence ( J:204336 )

• low and high grade in multiple organ sites

increased adenocarcinoma incidence ( J:204336 )

• in the mammary, pancreatic, lung and liver

increased mammary adenocarcinoma incidence ( J:204336 )

increased liver adenocarcinoma incidence ( J:204336 )

increased lung adenocarcinoma incidence ( J:204336 )

increased spindle cell carcinoma incidence ( J:204336 )

• low grade

increased sarcoma incidence ( J:204336 )

• low and high grade in multiple organ sites

integument

increased mammary adenocarcinoma incidence ( J:204336 )

liver/biliary system

increased hepatocellular carcinoma incidence ( J:204336 )

increased liver adenocarcinoma incidence ( J:204336 )

respiratory system

increased lung adenocarcinoma incidence ( J:204336 )