Analysis Tools|
Allele Symbol Allele Name Allele ID |
Tbx3tm1.1Moon targeted mutation 1.1, Anne M Moon MGI:5538551 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• most mice die before E10.5
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• authors state that mice exhibit cardiac morphology similar to that observed in Tbx3tm1Jcib homozygotes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• atrial arrhythmia in embryos
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Limb abnormalities and edema in Tbx3tm2Moon/Tbx3tm1.1Moon hypomorphs
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• most mice die between E13.5 and E15.5
• no mice survive to birth
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• most mice die between E13.5 and E15.5
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• cardiac conduction system hypoplasia without a change in cell proliferation or apoptosis
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• rare ventricular-arterial mal-alignment
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• large interventricular foramina in most mice at E13.5 to E14.5
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• at E10.5 to E12.5
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• atrial arrhythmia at E11.5 to E14.5
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• first detected at E11.5 and in most mice at E12.5
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• authors state that mice exhibit limb abnormalities similar to Tbx3tm1Pa homozygotes
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| N |
• mice exhibit normal yolk sacs and placenta
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• cardiac conduction system hypoplasia without a change in cell proliferation or apoptosis
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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