All Phenotypes Tbx3<tm2.1Moon> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tbx3^tm2.1Moon/Tbx3^tm2.1Moon	involves: 129 * BALB/cJ * C57BL/6 * FVB/N * SJL	MGI:5538605
hm2	Tbx3^tm2.1Moon/Tbx3^tm2.1Moon	involves: 129 * BALB/cJ * C57BL/6 * SJL	MGI:5538604

Allelic Composition	Tbx3^tm2.1Moon/Tbx3^tm2.1Moon
Genetic Background	involves: 129 * BALB/cJ * C57BL/6 * FVB/N * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tbx3^tm2.1Moon mutation (0 available); any Tbx3 mutation (49 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:179977 )

• some mice die suddenly

preweaning lethality, incomplete penetrance ( J:179977 )

• rare mice survive to adulthood

cardiovascular system

abnormal sinus arrhythmia ( J:179977 )

• sinus pauses in rare surviving adult mice

increased heart rate variability ( J:179977 )

• in rare surviving adult mice

decreased heart rate ( J:179977 )

• in one third of rare surviving adult mice

sinus bradycardia ( J:179977 )

• in rare surviving adult mice

irregular heartbeat ( J:179977 )

abnormal impulse conducting system conduction ( J:179977 )

• rare surviving adult mice exhibit a variety of arrhythmias including sinus bradycardia, sinus pauses, premature atrial contractions, junctional rhythm, AV block, likely ventricular pre-excitation, premature ventricular contractions and ventricular couplets consistent with global cardiac conduction

absent PR interval ( J:179977 )

• in adult mice

shortened PR interval ( J:179977 )

• in rare surviving adult mice

atrioventricular block ( J:179977 )

• in rare surviving adult mice

abnormal P wave ( J:179977 )

• fusion of P and QRS complex in adult mice

absent P wave ( J:179977 )

• in adult mice

abnormal QRS complex ( J:179977 )

• fusion of P and QRS complex in adult mice

prolonged QRS complex duration ( J:179977 )

• longer median QRS duration in rare surviving adult mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Histologic conduction system abnormalities in adult Tbx3^tm2.1Moon/Tbx3^tm2.1Moon mutants

mortality/aging

postnatal lethality, incomplete penetrance ( J:179977 )

• some mice survive to adulthood

prenatal lethality, incomplete penetrance ( J:179977 )

• most mice survive to birth

cardiovascular system

abnormal inferior vena cava morphology ( J:179977 )

• interrupted inferior vena cave with azygous continuation in newborn mice

sinoatrial node hypoplasia ( J:179977 )

• cardiac conduction system hypoplasia without a change in cell proliferation or apoptosis

abnormal cardiovascular development ( J:179977 )

• 1 fourth of newborn mice exhibit structural malformation, including tetralogy of Fallot, ventricular septal defect and interrupted inferior vena cave with azygous continuation

ventricular septal defect ( J:179977 )

• in newborn mice

increased cardiac muscle contractility ( J:179977 )

• in newborn mice

decreased heart rate ( J:179977 )

• atrial bradycardia in newborn mice

irregular heartbeat ( J:179977 )

• atrial arrhythmia at E12.5 and E13.5

• multiple arrhythmias in newborn mice

atrioventricular block ( J:179977 )

• at E13.5 or later

• second degree in newborn

prolonged QRS complex duration ( J:179977 )

• widened in newborn mice

limbs/digits/tail

absent carpal bone ( J:179977 )

abnormal digit morphology ( J:179977 )

• duplicated first digit on forelimbs

oligodactyly ( J:179977 )

• missing posterior digits

absent tarsus bones ( J:179977 )

absent ulna ( J:179977 )

absent fibula ( J:179977 )

embryo

embryo phenotype ( J:179977 )

N	• yolk sacs are normal

homeostasis/metabolism

edema ( J:179977 )

muscle

sinoatrial node hypoplasia ( J:179977 )

• cardiac conduction system hypoplasia without a change in cell proliferation or apoptosis

increased cardiac muscle contractility ( J:179977 )

• in newborn mice

skeleton

absent carpal bone ( J:179977 )

absent tarsus bones ( J:179977 )

absent ulna ( J:179977 )

absent fibula ( J:179977 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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