All Phenotypes Tbx3<tm2.1Moon> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tbx3^tm2.1Moon/Tbx3^tm2.1Moon	involves: 129 * BALB/cJ * C57BL/6 * FVB/N * SJL	MGI:5538605
hm2	Tbx3^tm2.1Moon/Tbx3^tm2.1Moon	involves: 129 * BALB/cJ * C57BL/6 * SJL	MGI:5538604

Allelic Composition	Tbx3^tm2.1Moon/Tbx3^tm2.1Moon
Genetic Background	involves: 129 * BALB/cJ * C57BL/6 * FVB/N * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tbx3^tm2.1Moon mutation (0 available); any Tbx3 mutation (49 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:179977 )

• some mice die suddenly

preweaning lethality, incomplete penetrance ( J:179977 )

• rare mice survive to adulthood

cardiovascular system

abnormal sinus arrhythmia ( J:179977 )

• sinus pauses in rare surviving adult mice

increased heart rate variability ( J:179977 )

• in rare surviving adult mice

decreased heart rate ( J:179977 )

• in one third of rare surviving adult mice

sinus bradycardia ( J:179977 )

• in rare surviving adult mice

irregular heartbeat ( J:179977 )

abnormal impulse conducting system conduction ( J:179977 )

• rare surviving adult mice exhibit a variety of arrhythmias including sinus bradycardia, sinus pauses, premature atrial contractions, junctional rhythm, AV block, likely ventricular pre-excitation, premature ventricular contractions and ventricular couplets consistent with global cardiac conduction

absent PR interval ( J:179977 )

• in adult mice

shortened PR interval ( J:179977 )

• in rare surviving adult mice

atrioventricular block ( J:179977 )

• in rare surviving adult mice

abnormal P wave ( J:179977 )

• fusion of P and QRS complex in adult mice

absent P wave ( J:179977 )

• in adult mice

abnormal QRS complex ( J:179977 )

• fusion of P and QRS complex in adult mice

prolonged QRS complex duration ( J:179977 )

• longer median QRS duration in rare surviving adult mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Histologic conduction system abnormalities in adult Tbx3^tm2.1Moon/Tbx3^tm2.1Moon mutants

mortality/aging

postnatal lethality, incomplete penetrance ( J:179977 )

• some mice survive to adulthood

prenatal lethality, incomplete penetrance ( J:179977 )

• most mice survive to birth

cardiovascular system

abnormal inferior vena cava morphology ( J:179977 )

• interrupted inferior vena cave with azygous continuation in newborn mice

sinoatrial node hypoplasia ( J:179977 )

• cardiac conduction system hypoplasia without a change in cell proliferation or apoptosis

abnormal cardiovascular development ( J:179977 )

• 1 fourth of newborn mice exhibit structural malformation, including tetralogy of Fallot, ventricular septal defect and interrupted inferior vena cave with azygous continuation

ventricular septal defect ( J:179977 )

• in newborn mice

increased cardiac muscle contractility ( J:179977 )

• in newborn mice

decreased heart rate ( J:179977 )

• atrial bradycardia in newborn mice

irregular heartbeat ( J:179977 )

• atrial arrhythmia at E12.5 and E13.5

• multiple arrhythmias in newborn mice

atrioventricular block ( J:179977 )

• at E13.5 or later

• second degree in newborn

prolonged QRS complex duration ( J:179977 )

• widened in newborn mice

limbs/digits/tail

absent carpal bone ( J:179977 )

abnormal digit morphology ( J:179977 )

• duplicated first digit on forelimbs

oligodactyly ( J:179977 )

• missing posterior digits

absent tarsus bones ( J:179977 )

absent ulna ( J:179977 )

absent fibula ( J:179977 )

embryo

embryo phenotype ( J:179977 )

N	• yolk sacs are normal

homeostasis/metabolism

edema ( J:179977 )

muscle

sinoatrial node hypoplasia ( J:179977 )

• cardiac conduction system hypoplasia without a change in cell proliferation or apoptosis

increased cardiac muscle contractility ( J:179977 )

• in newborn mice

skeleton

absent carpal bone ( J:179977 )

absent tarsus bones ( J:179977 )

absent ulna ( J:179977 )

absent fibula ( J:179977 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24