Phenotypes associated with this allele

• Allele Symbol: Selenow^em#Hwl
• Allele Name: endonuclease-mediated mutation, Han-Woong Lee
• Allele ID: MGI:5538611
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Selenow^em#Hwl/Selenow^em#Hwl	C57BL/6-Selenow^em#Hwl	MGI:6390550

Genotype
MGI:6390550

hm1

• Allelic Composition: Selenow^em#Hwl/Selenow^em#Hwl
• Genetic Background: C57BL/6-Selenow^em#Hwl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

abnormal osteoclast differentiation ( J:317012 )

• osteoclast precursors exhibit decreased osteoclast differentiation

decreased osteoclast cell number ( J:317012 )

• fewer TRAP-positive osteoclasts are seen on the surface of trabecular bone

• however, numbers of osteoblasts are normal

increased bone mineral density ( J:317012 )

increased trabecular bone volume ( J:317012 )

decreased bone trabecular spacing ( J:317012 )

• decrease in trabecular bone separation

increased trabecular bone thickness ( J:317012 )

increased bone mass ( J:317012 )

growth/size/body

increased body weight ( J:317012 )

• slight increase in body weight

• however, all other appearances including body size, tooth eruption, locomotor activity and bone-related parameters in the serum are normal

hematopoietic system

abnormal osteoclast differentiation ( J:317012 )

• osteoclast precursors exhibit decreased osteoclast differentiation

decreased osteoclast cell number ( J:317012 )

• fewer TRAP-positive osteoclasts are seen on the surface of trabecular bone

• however, numbers of osteoblasts are normal

immune system

abnormal osteoclast differentiation ( J:317012 )

• osteoclast precursors exhibit decreased osteoclast differentiation

decreased osteoclast cell number ( J:317012 )

• fewer TRAP-positive osteoclasts are seen on the surface of trabecular bone

• however, numbers of osteoblasts are normal

cellular

abnormal osteoclast differentiation ( J:317012 )

• osteoclast precursors exhibit decreased osteoclast differentiation

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:282110 )

♂N • male mice fed a high-fat diet show no differences from wild-type mice on obesity, food intake, glucose tolerance, insulin sensitivity and resistance, and oxidative stress