Phenotypes associated with this allele

• Allele Symbol: Mlkl^em1Jhan
• Allele Name: endonuclease-mediated mutation 1, Jiahuai Han
• Allele ID: MGI:5538612
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mlkl^em1Jhan/Mlkl^em1Jhan	involves: C57BL/6	MGI:5538616

Genotype
MGI:5538616

hm1

• Allelic Composition: Mlkl^em1Jhan/Mlkl^em1Jhan
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:204622 )

N • mice exhibit normal mortality in response to polymicrobial septic shock following cecal ligation and perforation

immune system

immune system phenotype ( J:204622 )

N • mice exhibit normal T cell, macrophage and neutrophil development

abnormal macrophage physiology ( J:204622 )

• macrophages are resistant to LPS and pan-caspase inhibitor N-benzyloxycarbonyl-valyl-alanyl-aspartic-acid (O-methyl)-fluoromethylketone (zVAD)- or oxidized low-density lipoprotein (oxLDL) and zVAD-induced necroptosis compared with wild-type cells

cellular

decreased sensitivity to induced cell death ( J:204622 )

• macrophages are resistant to LPS and pan-caspase inhibitor N-benzyloxycarbonyl-valyl-alanyl-aspartic-acid (O-methyl)-fluoromethylketone (zVAD)- or oxidized low-density lipoprotein (oxLDL) and zVAD-induced necroptosis compared with wild-type cells

• mouse embryonic fibroblasts exhibit resistance to TNF, cycloheximide (CHX) and zVAD-induced cell death compared with wild-type cells

• however, mouse embryonic fibroblasts exhibit normal cell death induced by TNF and CHX; TNF and Smac mimetic (SmacM); TRAIL and CHX; TRAIL, CHX and zVAD; etoposide or staurosporine (STS)

homeostasis/metabolism

decreased susceptibility to injury ( J:204622 )

• mice are protected from cerulean-induced acute pancreatitis compared with wild-type mice

• however, mice exhibit normal mortality in response to polymicrobial septic shock following cecal ligation and perforation

hematopoietic system

abnormal macrophage physiology ( J:204622 )

• macrophages are resistant to LPS and pan-caspase inhibitor N-benzyloxycarbonyl-valyl-alanyl-aspartic-acid (O-methyl)-fluoromethylketone (zVAD)- or oxidized low-density lipoprotein (oxLDL) and zVAD-induced necroptosis compared with wild-type cells