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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Lck-cre)#Jxm
transgene insertion, Jamey Marth
MGI:5538658
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Nop53tm2.1Asuz/Nop53tm2.1Asuz
Trp53tm1Tyj/Trp53tm1Tyj
Tg(Lck-cre)#Jxm/0
involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * CBA MGI:5906184
cn2
Cdkn2atm1Cjs/Cdkn2atm1Cjs
Nop53tm2.1Asuz/Nop53tm2.1Asuz
Tg(Lck-cre)#Jxm/0
involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * CBA MGI:5906183
cn3
Nop53tm2.1Asuz/Nop53tm2.1Asuz
Tg(Lck-cre)#Jxm/0
involves: 129P2/OlaHsd * C57BL/6 * CBA MGI:5906173
cn4
Pgap3tm1Ymra/Pgap3tm1Ymra
Tg(Lck-cre)#Jxm/0
involves: C57BL/6 * CBA MGI:5538668


Genotype
MGI:5906184
cn1
Allelic
Composition
Nop53tm2.1Asuz/Nop53tm2.1Asuz
Trp53tm1Tyj/Trp53tm1Tyj
Tg(Lck-cre)#Jxm/0
Genetic
Background
involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nop53tm2.1Asuz mutation (0 available); any Nop53 mutation (28 available)
Tg(Lck-cre)#Jxm mutation (0 available)
Trp53tm1Tyj mutation (12 available); any Trp53 mutation (240 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• Trp53 KO rescues thymocyte reducing phenotype of Nop53 KO

hematopoietic system
• Trp53 KO rescues thymocyte reducing phenotype of Nop53 KO

immune system
• Trp53 KO rescues thymocyte reducing phenotype of Nop53 KO




Genotype
MGI:5906183
cn2
Allelic
Composition
Cdkn2atm1Cjs/Cdkn2atm1Cjs
Nop53tm2.1Asuz/Nop53tm2.1Asuz
Tg(Lck-cre)#Jxm/0
Genetic
Background
involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2atm1Cjs mutation (7 available); any Cdkn2a mutation (67 available)
Nop53tm2.1Asuz mutation (0 available); any Nop53 mutation (28 available)
Tg(Lck-cre)#Jxm mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• thymocyte level was 5% of control

hematopoietic system
• thymocyte level was 5% of control

immune system
• thymocyte level was 5% of control




Genotype
MGI:5906173
cn3
Allelic
Composition
Nop53tm2.1Asuz/Nop53tm2.1Asuz
Tg(Lck-cre)#Jxm/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nop53tm2.1Asuz mutation (0 available); any Nop53 mutation (28 available)
Tg(Lck-cre)#Jxm mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• thymocyte level was 5% of control

hematopoietic system
• thymocyte level was 5% of control

immune system
• thymocyte level was 5% of control




Genotype
MGI:5538668
cn4
Allelic
Composition
Pgap3tm1Ymra/Pgap3tm1Ymra
Tg(Lck-cre)#Jxm/0
Genetic
Background
involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pgap3tm1Ymra mutation (1 available); any Pgap3 mutation (28 available)
Tg(Lck-cre)#Jxm mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• mice do not develop anti-DNA antibodies





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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory