All Phenotypes Spo11<tm3Rdco> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Spo11^tm3Rdco/Spo11^tm3Rdco	involves: C57BL/6	MGI:5538731
ht2	Spo11^tm1.1Gvpc/Spo11^tm3Rdco	involves: C57BL/6	MGI:5538721

Allelic Composition	Spo11^tm3Rdco/Spo11^tm3Rdco
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spo11^tm3Rdco mutation (0 available); any Spo11 mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal reproductive system morphology ( J:202231 )

• authors state that mice exhibit identical phenotype as Spo11^tm1Rdco homozygotes

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Absence of germ cells beyond the spermatocyte stage and small ovaries with diminished number of follicles in Spo11^tm1.1Gvpc/Spo11^tm1.1Gvpc mice and absence of ovarian follicles in Spo11^tm1.1Gvpc/Spo11^tm3Rdco mice

mortality/aging

early reproductive senescence ( J:202231 )

• while young female mice produce progeny, no viable litters are obtained in mice older than 6 months

reproductive system

azoospermia ( J:202231 )

• no germ cells beyond the spermatocyte stage

abnormal X-Y chromosome synapsis during male meiosis ( J:202231 )

arrest of male meiosis ( J:202231 )

• with a failure of complete synapsis

decreased mature ovarian follicle number ( J:202231 )

small ovary ( J:202231 )

small testis ( J:202231 )

early reproductive senescence ( J:202231 )

• while young female mice produce progeny, no viable litters are obtained in mice older than 6 months

male infertility ( J:202231 )

homeostasis/metabolism

abnormal double-strand DNA break repair ( J:202231 )

• decreased number of meiotic double strand breaks in spermatocytes and oocytes

• deficiency of double strand breaks at the chromosomal ends

cellular