Phenotypes associated with this allele

• Allele Symbol: Slirp^tm1.2Pjle
• Allele Name: targeted mutation 1.2, Peter J Leedman
• Allele ID: MGI:5538716
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Slirp^tm1.2Pjle/Slirp^tm1.2Pjle	involves: C57BL/6	MGI:5538717

Genotype
MGI:5538717

hm1

• Allelic Composition: Slirp^tm1.2Pjle/Slirp^tm1.2Pjle
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Annulus and mitochondrial disruption in Slirp^tm1.2Pjle/Slirp^tm1.2Pjle sperm

mortality/aging

preweaning lethality, incomplete penetrance ( J:204433 )

• number of homozygous pups is at lower than the expected Mendelian ratio at weaning

reproductive system

reproductive system phenotype ( J:204433 )

♂N • normal sperm production and normal testis weight

abnormal sperm annulus morphology ( J:204433 )

♂ • abnormal gap at the mid-piece/annulus junction

abnormal sperm mitochondrial morphology ( J:204433 )

♂ • less defined mitochondrial cisternae and the mitochondrial matrix appears more electron dense

decreased sperm progressive motility ( J:204433 )

♂ • significant decrease in progressive motility but no significant difference in total sperm motility

reduced male fertility ( J:204433 )

♂ • sire smaller litters when crossed to wild-type females(average litter size 4.5 pups compared to 6.9 pups for wild-type males)

cellular

abnormal sperm annulus morphology ( J:204433 )

♂ • abnormal gap at the mid-piece/annulus junction

abnormal sperm mitochondrial morphology ( J:204433 )

♂ • less defined mitochondrial cisternae and the mitochondrial matrix appears more electron dense

decreased sperm progressive motility ( J:204433 )

♂ • significant decrease in progressive motility but no significant difference in total sperm motility