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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Dbitm2.2Smdp
targeted mutation 2.2, Susanne Mandrup
MGI:5538737
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Dbitm2.1Smdp/Dbitm2.2Smdp
Tg(KRT14-cre)1Cgn/0 		involves: C57BL/6 * DBA/2 * FVB/N MGI:5538741
cn2
 		Dbitm2.1Smdp/Dbitm2.2Smdp
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ 		involves: C57BL/6 * DBA * FVB/N MGI:5538740


Genotype
MGI:5538741
cn1
Allelic
Composition		 Dbitm2.1Smdp/Dbitm2.2Smdp
Tg(KRT14-cre)1Cgn/0
Genetic
Background		 involves: C57BL/6 * DBA/2 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dbitm2.1Smdp mutation (0 available); any Dbi mutation (25 available)
Dbitm2.2Smdp mutation (0 available); any Dbi mutation (25 available)
Tg(KRT14-cre)1Cgn mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
integument
impaired skin barrier function ( J:204137 )
• compromised epidermal barrier function at postnatal day 21
greasy coat ( J:204137 )
• greasy and tousled appearance identical to that in homozygous germ line null mice

adipose tissue
abnormal white adipose tissue physiology ( J:204137 )
• elevated lypolysis in isolated inguinal WAT

homeostasis/metabolism
impaired skin barrier function ( J:204137 )
• compromised epidermal barrier function at postnatal day 21
increased liver cholesterol level ( J:204137 )
• greater accumulation of cholesteryl esters at P21
• accumulation is less than in homozygous germ line null mice

liver/biliary system
increased liver cholesterol level ( J:204137 )
• greater accumulation of cholesteryl esters at P21
• accumulation is less than in homozygous germ line null mice
abnormal liver physiology ( J:204137 )
• expression analysis in fostered pups indicates a defect in liver adaptation to weaning




Genotype
MGI:5538740
cn2
Allelic
Composition		 Dbitm2.1Smdp/Dbitm2.2Smdp
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic
Background		 involves: C57BL/6 * DBA * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dbitm2.1Smdp mutation (0 available); any Dbi mutation (25 available)
Dbitm2.2Smdp mutation (0 available); any Dbi mutation (25 available)
Speer6-ps1Tg(Alb-cre)21Mgn mutation (6 available); any Speer6-ps1 mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:204137 )
• normal development and gross morphology at postnatal day 21
• no defect in liver adaptation to weaning is detected unlike in homozygous germ line null mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory