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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Kittm1(cre/ERT2)Dsa
targeted mutation 1, Dieter Saur
MGI:5543260
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Kittm1(cre/ERT2)Dsa/Kit+
Prkg1tm2Naw/Prkg1tm2Naw 		involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 MGI:5545743
cn2
 		Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sor+
Kittm1(cre/ERT2)Dsa/Kit+ 		involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6 MGI:5545742


Genotype
MGI:5545743
cn1
Allelic
Composition		 Kittm1(cre/ERT2)Dsa/Kit+
Prkg1tm2Naw/Prkg1tm2Naw
Genetic
Background		 involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kittm1(cre/ERT2)Dsa mutation (0 available); any Kit mutation (182 available)
Prkg1tm2Naw mutation (0 available); any Prkg1 mutation (60 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
abnormal gastrointestinal motility ( J:204737 )
• significant GI motor dysfunction is observed with tamoxifen treatment
abnormal intestinal peristalsis ( J:204737 )
• change in contraction frequency is observed in tamoxifen-treated mutants
• nitric oxide-dependent nitrergic slow component of the inhibitory junction potential in circular smooth muscle cells of the colon is abolished in tamoxifen-treated mice
abnormal intestinal transit time ( J:204737 )
• GI transit time is increased by about 2 hours in treated mutants

muscle
abnormal intestinal peristalsis ( J:204737 )
• change in contraction frequency is observed in tamoxifen-treated mutants
• nitric oxide-dependent nitrergic slow component of the inhibitory junction potential in circular smooth muscle cells of the colon is abolished in tamoxifen-treated mice




Genotype
MGI:5545742
cn2
Allelic
Composition		 Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sor+
Kittm1(cre/ERT2)Dsa/Kit+
Genetic
Background		 involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(DTA)Jpmb mutation (2 available); any Gt(ROSA)26Sor mutation (993 available)
Kittm1(cre/ERT2)Dsa mutation (0 available); any Kit mutation (182 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
abnormal gastrointestinal motility ( J:204737 )
• significantly disturbed after 3 days of tamoxifen treatment (which results in loss of more than 50% of insterstitial cells of Cajal (ICCs)
abnormal intestinal peristalsis ( J:204737 )
• tamoxifen-treated mice show dysrhythmia resulting from uncoordinated spontaneous contractions and lack of slow-wave type electrical activity
abnormal intestinal transit time ( J:204737 )
• total GI transit time is increased to more than 5 hours; similar transit time is measured in tamoxifen-treated mutants that have been repopulated with wild-type mast cells (by adaptive BM transplant)
impaired gastric peristalsis ( J:204737 )
• tamoxifen-treated mice have delayed gastric emptying

nervous system
abnormal synaptic transmission ( J:204737 )
• in tamoxifen treated mice, excitatory enteric neurotransmission is blocked as result of ICC depletion

muscle
abnormal intestinal peristalsis ( J:204737 )
• tamoxifen-treated mice show dysrhythmia resulting from uncoordinated spontaneous contractions and lack of slow-wave type electrical activity




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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory