mortality/aging
• Background Sensitivity: mice on a C57BL/6J congenic background do not survive more than 2 days after birth unlike mice on a mixed background that are viable
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• Background Sensitivity: most mice on a C57BL/6J congenic background die within a day after birth unlike mice on a mixed background that are viable
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embryo
• at E14.5 due to delayed development
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• at E14.5 due to delayed development
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• delayed with reduced mitotic activity
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growth/size/body
• evident mid-gestation (E14.5 and E16.5)
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cardiovascular system
• at E14.5 due to delayed development
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skeleton
• delay in the replacement of cartilaginous ribs with ossified ribs at E16.5
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cellular
• in the placenta
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muscle
• at E14.5 due to delayed development
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