Phenotypes associated with this allele

• Allele Symbol: Sgo1^{Gt(neo-btk)1Dai}
• Allele Name: gene trap 1, Wei Dai
• Allele ID: MGI:5543407
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sgo1^Gt(neo-btk)1Dai/Sgo1^Gt(neo-btk)1Dai	involves: 129S4/SvJae * C57BL/6	MGI:5543789
ht2	Sgo1^Gt(neo-btk)1Dai/Sgo1^+	involves: 129S4/SvJae * C57BL/6	MGI:5543791

Genotype
MGI:5543789

hm1

• Allelic Composition: Sgo1^{Gt(neo-btk)1Dai}/Sgo1^{Gt(neo-btk)1Dai}
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality ( J:204809 )

• no homozygous pups are produced from heterozygote x heterozygote matings

Genotype
MGI:5543791

ht2

• Allelic Composition: Sgo1^{Gt(neo-btk)1Dai}/Sgo1⁺
• Genetic Background: involves: 129S4/SvJae * C57BL/6

neoplasm

increased colon tumor incidence ( J:204809 )

• frequency of colonic tumors is increased by 5-fold in mutant mice as compared to controls 12 weeks after exposure to the colon carcinogen azoxymethane (AOM)

• most tumors are adenomas

cellular

aneuploidy ( J:204809 )

• many mitotic mouse embryonic fibroblasts (MEFs) are polyploid or aneuploid

polyploidy ( J:204809 )

• many mitotic MEFs are polyploid or aneuploid

increased sensitivity to induced cell death ( J:204809 )

• cell death rate is higher than wild type (60% vs. 25%) as determined by sub-G₁ DNA content in colonic mucosa following exposure to AOM

chromosomal instability ( J:204809 )

• misaligned chromosomes are observed in metaphase cells from MEFs

• increased frequency of anaphase bridge or lagging chromosomes is observed in MEFs during anaphase

• MEFs often contain more than two microtubule organization centers

• extra centrosomal foci are observed in mitotic MEFs and bone marrow cells

digestive/alimentary system

abnormal crypts of Lieberkuhn morphology ( J:204809 )

• increased number aberrant crypt foci (ACF) and multicrypt ACF 12 weeks after exposure to the colon carcinogen AOM

• frequency of aberrant crypt foci is three times higher in mutant mice than in controls

increased colon tumor incidence ( J:204809 )

• frequency of colonic tumors is increased by 5-fold in mutant mice as compared to controls 12 weeks after exposure to the colon carcinogen azoxymethane (AOM)

• most tumors are adenomas

endocrine/exocrine glands

abnormal crypts of Lieberkuhn morphology ( J:204809 )

• increased number aberrant crypt foci (ACF) and multicrypt ACF 12 weeks after exposure to the colon carcinogen AOM

• frequency of aberrant crypt foci is three times higher in mutant mice than in controls