Phenotypes associated with this allele

• Allele Symbol: Siglecf^tm1.2Avrk
• Allele Name: targeted mutation 1.2, Ajit Varki
• Allele ID: MGI:5543479
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Siglecf^tm1.2Avrk/Siglecf^tm1.2Avrk	B6.129(FVB)-Siglecf^tm1.2Avrk	MGI:5543491

Genotype
MGI:5543491

hm1

• Allelic Composition: Siglecf^tm1.2Avrk/Siglecf^tm1.2Avrk
• Genetic Background: B6.129(FVB)-Siglecf^tm1.2Avrk

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:204811 )

N • mice exhibit normal baseline total blood cell counts, platelet counts, and blood chemistries and innate immune response in air-pouch-LPS inflammation, group A steptococus skin infection or oxazolone-ear painting

abnormal eosinophil differentiation ( J:204811 )

• increased metamyelocytic eosinophil precursors in ovalbumin-treated mice

increased eosinophil cell number ( J:204811 )

• in the blood and bone marrow of mice treated with ovalbumin

• however, baseline levels are normal

abnormal eosinophil physiology ( J:204811 )

• after ovalbumin challenge, eosinophil resolution is delayed and peribronchial eosinophil apoptosis is impaired compared to in wild-type mice

lung inflammation ( J:204811 )

• in an ovalbumin-challenge, mice exhibit more prominent peribronchial eosinophil infiltration compared with wild-type mice

• after ovalbumin challenge, eosinophil resolution is delayed and peribronchial eosinophil apoptosis is impaired compared to in wild-type mice

• however, there is no overall increase in numbers of infiltrating CD4+ cells or airway resistance

cellular

abnormal eosinophil differentiation ( J:204811 )

• increased metamyelocytic eosinophil precursors in ovalbumin-treated mice

respiratory system

lung inflammation ( J:204811 )

• in an ovalbumin-challenge, mice exhibit more prominent peribronchial eosinophil infiltration compared with wild-type mice

• after ovalbumin challenge, eosinophil resolution is delayed and peribronchial eosinophil apoptosis is impaired compared to in wild-type mice

• however, there is no overall increase in numbers of infiltrating CD4+ cells or airway resistance

hematopoietic system

abnormal eosinophil differentiation ( J:204811 )

• increased metamyelocytic eosinophil precursors in ovalbumin-treated mice

increased eosinophil cell number ( J:204811 )

• in the blood and bone marrow of mice treated with ovalbumin

• however, baseline levels are normal

abnormal eosinophil physiology ( J:204811 )

• after ovalbumin challenge, eosinophil resolution is delayed and peribronchial eosinophil apoptosis is impaired compared to in wild-type mice