All Phenotypes Car7<tm1.1Kkai> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Car7^tm1.1Kkai/Car7^tm1.1Kkai	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:5543610
cx2	Car2ⁿ/Car2ⁿ Car7^tm1.1Kkai/Car7^tm1.1Kkai	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2J	MGI:5543611

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

environmentally induced seizures ( J:200079 )

• mice exposed to hyperthermia fail to exhibit progression of seizures beyond score 3 with complete absence of electrographic seizures compared with wild-type mice

• mice exhibit atypical experimental febrile seizures compared with wild-type mice

abnormal GABA-mediated receptor currents ( J:200079 )

• under current clamp conditions, the slope of the depolarizing shift is lower than in wild-type neurons

• GABA application injected at the stratum radiatum and stratum lacunosum-moleculare border evokes hardly any spiking even with the longest puff compared with wild-type neurons

• dendritic GABA-evoked depolarization is smaller in neurons from P12 to P16 neurons compared with wild-type neurons

• however, measurement under voltage clamp conditions are normal

behavior/neurological

environmentally induced seizures ( J:200079 )

• mice exposed to hyperthermia fail to exhibit progression of seizures beyond score 3 with complete absence of electrographic seizures compared with wild-type mice

• mice exhibit atypical experimental febrile seizures compared with wild-type mice

Allelic Composition	Car2ⁿ/Car2ⁿ Car7^tm1.1Kkai/Car7^tm1.1Kkai
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Car2ⁿ mutation (1 available); any Car2 mutation (21 available)
Car7^tm1.1Kkai mutation (0 available); any Car7 mutation (17 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal GABA-mediated receptor currents ( J:200079 )

• dendritic GABA-evoked depolarization is smaller in neurons from >P35 compared with wild-type neurons

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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