All Phenotypes Rock1<tm1.1Itl> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Rock1^tm1.1Itl
targeted mutation 1.1, inGenious Targeting Laboratory
MGI:5543630

Summary

6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rock1^tm1.1Itl/Rock1^tm1.1Itl	involves: 129S4/SvJaeSor * C57BL/6 * FVB/N	MGI:5543675
cn2	Rock1^tm1.1Itl/Rock1^tm1.1Itl	involves: 129S4/SvJaeSor * C57BL/6 * FVB/N	MGI:5543679
cn3	Rock1^tm1.1Itl/Rock1^tm1.1Itl	Not Specified	MGI:5556295
cn4	Rock1^tm1.1Itl/Rock1^tm1.1Itl Tg(Pomc1-cre)16Lowl/0	involves: 129S4/SvJaeSor * C57BL/6 * FVB/N	MGI:5543676
cn5	Rock1^tm1.1Itl/Rock1^tm1.1Itl Tg(Npy-hrGFP)1Lowl/0 Tg(Pomc1-cre)16Lowl/0	involves: 129S4/SvJaeSor * C57BL/6 * FVB/N	MGI:5543677
cn6	Rock1^tm1.1Itl/Rock1^tm1.1Itl Agrp^tm1(cre)Lowl/Agrp⁺	involves: 129S4/SvJaeSor * C57BL/6 * FVB/N	MGI:5543678

Allelic Composition	Rock1^tm1.1Itl/Rock1^tm1.1Itl
Genetic Background	involves: 129S4/SvJaeSor * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rock1^tm1.1Itl mutation (0 available); any Rock1 mutation (60 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

growth/size/body region phenotype ( J:204885 )

N	• mice exhibit normal body weight

Allelic Composition	Rock1^tm1.1Itl/Rock1^tm1.1Itl
Genetic Background	involves: 129S4/SvJaeSor * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rock1^tm1.1Itl mutation (0 available); any Rock1 mutation (60 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

adipose tissue

increased total body fat amount ( J:204885 )

• following injection of a cre-expressing adenovirus in the hypothalamus

behavior/neurological

increased food intake ( J:204885 )

• following injection of a cre-expressing adenovirus in the hypothalamus

growth/size/body

increased body weight ( J:204885 )

• following injection of a cre-expressing adenovirus in the hypothalamus

Allelic Composition	Rock1^tm1.1Itl/Rock1^tm1.1Itl
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rock1^tm1.1Itl mutation (0 available); any Rock1 mutation (60 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal autophagy ( J:207251 )

• upon starvation, mouse embryonic fibroblasts transfected with a cre-expressing adenovirus exhibit decreased LC3 punctae compared with wild-type cells

homeostasis/metabolism

abnormal autophagy ( J:207251 )

• upon starvation, mouse embryonic fibroblasts transfected with a cre-expressing adenovirus exhibit decreased LC3 punctae compared with wild-type cells

Allelic Composition	Rock1^tm1.1Itl/Rock1^tm1.1Itl Tg(Pomc1-cre)16Lowl/0
Genetic Background	involves: 129S4/SvJaeSor * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rock1^tm1.1Itl mutation (0 available); any Rock1 mutation (60 available)
Tg(Pomc1-cre)16Lowl mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

adipose tissue

increased total body fat amount ( J:204885 )

increased epididymal fat pad weight ( J:204885 )

increased mesenteric fat pad weight ( J:204885 )

increased renal fat pad weight ( J:204885 )

• perirenal

homeostasis/metabolism

increased circulating insulin level ( J:204885 )

• at 20 weeks

increased circulating leptin level ( J:204885 )

• at 20 weeks

insulin resistance ( J:204885 )

• modest defect in the ability of insulin to decrease blood glucose

behavior/neurological

increased food intake ( J:204885 )

decreased locomotor activity ( J:204885 )

• during the dark phase

• however, movement during the light phase is normal

growth/size/body

increased body weight ( J:204885 )

skeleton

skeleton phenotype ( J:204885 )

N	• mice exhibit normal femur length, bone mineral density and bone mineral content

Allelic Composition	Rock1^tm1.1Itl/Rock1^tm1.1Itl Tg(Npy-hrGFP)1Lowl/0 Tg(Pomc1-cre)16Lowl/0
Genetic Background	involves: 129S4/SvJaeSor * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rock1^tm1.1Itl mutation (0 available); any Rock1 mutation (60 available)
Tg(Npy-hrGFP)1Lowl mutation (1 available)
Tg(Pomc1-cre)16Lowl mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal nervous system electrophysiology ( J:204885 )

• leptin fails to depolarize POMC+ neurons and increase firing rate unlike in control neurons

Allelic Composition	Rock1^tm1.1Itl/Rock1^tm1.1Itl Agrp^tm1(cre)Lowl/Agrp⁺
Genetic Background	involves: 129S4/SvJaeSor * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agrp^tm1(cre)Lowl mutation (1 available); any Agrp mutation (17 available)
Rock1^tm1.1Itl mutation (0 available); any Rock1 mutation (60 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

adipose tissue

increased total body fat amount ( J:204885 )

increased epididymal fat pad weight ( J:204885 )

increased mesenteric fat pad weight ( J:204885 )

increased renal fat pad weight ( J:204885 )

• perirenal

growth/size/body

increased body weight ( J:204885 )

obese ( J:204885 )

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