Phenotypes associated with this allele

• Allele Symbol: Rasip1^tm1.1Wye
• Allele Name: targeted mutation 1.1, Weilan Ye
• Allele ID: MGI:5543662
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rasip1^tm1.1Wye/Rasip1^tm1.1Wye	C57BL/6-Rasip1^tm1.1Wye	MGI:5543665

Genotype
MGI:5543665

hm1

• Allelic Composition: Rasip1^tm1.1Wye/Rasip1^tm1.1Wye
• Genetic Background: C57BL/6-Rasip1^tm1.1Wye

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:203698 )

• no viable mice are observed beyond E10.5

cardiovascular system

abnormal dorsal aorta morphology ( J:203698 )

• irregular width along the rostral-caudal axis

• highly distorted at E9.0 with collapse, breakage and dilation at different axial positions

• increased variation in the luminal areas

dilated dorsal aorta ( J:203698 )

• at E9.0

abnormal vascular endothelial cell morphology ( J:203698 )

• disorganized or dispersed in some vessels

pericardial edema ( J:203698 )

• at E9.0

hemorrhage ( J:203698 )

• prominent at E9.0 with large pools of erythrocytes at random location

• exacerbated at E10.5

• red blood cells collect within aberrant vessels or extravascular space

embryo

decreased embryo size ( J:203698 )

• slightly at E9.0

• at E10.5

abnormal vitelline vascular remodeling ( J:203698 )

• yolk sac vasculature fails to remodel

integument

pallor ( J:203698 )

• at E9.0

homeostasis/metabolism

edema ( J:203698 )

• exacerbated at E10.5

pericardial edema ( J:203698 )

• at E9.0

growth/size/body

decreased embryo size ( J:203698 )

• slightly at E9.0

• at E10.5