Phenotypes associated with this allele

• Allele Symbol: Ehmt1^tm2Yshk
• Allele Name: targeted mutation 2, Yoichi Shinkai
• Allele ID: MGI:5543772
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ehmt1^tm2Yshk/Ehmt1^tm2Yshk	Not Specified	MGI:5543775
cn2	Ehmt1^tm2Yshk/Ehmt1^tm2Yshk Nkx2-5^tm1(cre)Rjs/Nkx2-5^+	involves: 129S7/SvEvBrd	MGI:5543776
cn3	Ehmt1^tm2Yshk/Ehmt1^tm2Yshk Tg(Myh6-cre)2182Mds/0	involves: FVB/N	MGI:5543777

Genotype
MGI:5543775

hm1

• Allelic Composition: Ehmt1^tm2Yshk/Ehmt1^tm2Yshk
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:204470 )

• mice are viable and fertile

Genotype
MGI:5543776

cn2

• Allelic Composition: Ehmt1^tm2Yshk/Ehmt1^tm2Yshk; Nkx2-5^tm1(cre)Rjs/Nkx2-5⁺
• Genetic Background: involves: 129S7/SvEvBrd

mortality/aging

premature death ( J:204470 )

• one mouse that survived to weaning died shortly after

neonatal lethality, incomplete penetrance ( J:204470 )

• despite being present at E18.5, only one mouse was found at weaning and died shortly after

• no dead mice are detected before weaning indicating neonatal lethality

cardiovascular system

decreased atrioventricular cushion size ( J:204470 )

abnormal mitral valve cusp morphology ( J:204470 )

• the anterior leaflet has an apparent cleft

absent tricuspid valve cusps ( J:204470 )

atrioventricular septal defect ( J:204470 )

Genotype
MGI:5543777

cn3

• Allelic Composition: Ehmt1^tm2Yshk/Ehmt1^tm2Yshk; Tg(Myh6-cre)2182Mds/0
• Genetic Background: involves: FVB/N

normal phenotype

no abnormal phenotype detected ( J:204470 )

• mice are born, develop and show no apparent abnormalities in appearance, cardiogenesis or fertility