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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gt(ROSA)26Sortm2(tTA,CMV*1-KIAA1549/BRAF,-EGFP)Gtm
targeted mutation 2, David H Gutmann
MGI:5543802
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Gt(ROSA)26Sortm2(tTA,CMV*1-KIAA1549/BRAF,-EGFP)Gtm/Gt(ROSA)26Sor+ involves: 129S6/SvEvTac * C57BL/6 MGI:5543813
cn2
 		Gt(ROSA)26Sortm2(tTA,CMV*1-KIAA1549/BRAF,-EGFP)Gtm/Gt(ROSA)26Sor+
Tg(Fabp7-cre,-lacZ)3Gtm/0 		involves: 129S6/SvEvTac * C57BL/6 * CBA MGI:5543815
cn3
 		Gt(ROSA)26Sortm2(tTA,CMV*1-KIAA1549/BRAF,-EGFP)Gtm/Gt(ROSA)26Sor+
Tg(GFAP-cre)#Gtm/0 		involves: 129S6/SvEvTac * C57BL/6 * CBA MGI:5543816
cn4
 		Gt(ROSA)26Sortm2(tTA,CMV*1-KIAA1549/BRAF,-EGFP)Gtm/Gt(ROSA)26Sor+
Ifi208Tg(Cspg4-cre)1Akik/Ifi208+ 		involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL MGI:5543814


Genotype
MGI:5543813
cn1
Allelic
Composition		 Gt(ROSA)26Sortm2(tTA,CMV*1-KIAA1549/BRAF,-EGFP)Gtm/Gt(ROSA)26Sor+
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm2(tTA,CMV*1-KIAA1549/BRAF,-EGFP)Gtm mutation (0 available); any Gt(ROSA)26Sor mutation (993 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal neuronal stem cell physiology ( J:204469 )
• increased neuronal stem cell proliferation following transfection with a cre-expressing adenovirus
increased neuronal stem cell self-renewal ( J:204469 )
• following transfection with a cre-expressing adenovirus




Genotype
MGI:5543815
cn2
Allelic
Composition		 Gt(ROSA)26Sortm2(tTA,CMV*1-KIAA1549/BRAF,-EGFP)Gtm/Gt(ROSA)26Sor+
Tg(Fabp7-cre,-lacZ)3Gtm/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm2(tTA,CMV*1-KIAA1549/BRAF,-EGFP)Gtm mutation (0 available); any Gt(ROSA)26Sor mutation (993 available)
Tg(Fabp7-cre,-lacZ)3Gtm mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:204469 )
• mice are born in Mendelian ratios but do not survive beyond 8 to 10 weeks

digestive/alimentary system
abnormal digestive system morphology ( J:204469 )
• abnormal alimentary canal, ranging from severely swollen stomachs to blackened hindguts
abnormal hindgut morphology ( J:204469 )
• blackened hindguts in some mice
enlarged stomach ( J:204469 )
• severely swollen in some mice
abnormal digestive system physiology ( J:204469 )
• mice become malnourished

nervous system
nervous system phenotype ( J:204469 )
N
• cell proliferation and survival are normal in the cerebellum
increased astrocyte number ( J:204469 )
• GFAP+ and S100B+ without a change in proliferation or apoptosis rates




Genotype
MGI:5543816
cn3
Allelic
Composition		 Gt(ROSA)26Sortm2(tTA,CMV*1-KIAA1549/BRAF,-EGFP)Gtm/Gt(ROSA)26Sor+
Tg(GFAP-cre)#Gtm/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm2(tTA,CMV*1-KIAA1549/BRAF,-EGFP)Gtm mutation (0 available); any Gt(ROSA)26Sor mutation (993 available)
Tg(GFAP-cre)#Gtm mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:204469 )
N
• mice exhibit normal GFAP+ and S100B+ astrocytes cell numbers




Genotype
MGI:5543814
cn4
Allelic
Composition		 Gt(ROSA)26Sortm2(tTA,CMV*1-KIAA1549/BRAF,-EGFP)Gtm/Gt(ROSA)26Sor+
Ifi208Tg(Cspg4-cre)1Akik/Ifi208+
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm2(tTA,CMV*1-KIAA1549/BRAF,-EGFP)Gtm mutation (0 available); any Gt(ROSA)26Sor mutation (993 available)
Ifi208Tg(Cspg4-cre)1Akik mutation (1 available); any Ifi208 mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:204469 )
N
• mice exhibit normal GFAP+ and S100B+ astrocytes cell numbers




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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory