Analysis Tools
immune system
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• untreated mice exhibit normal subsets of dendritic cells and other cellularities
• diphtheria toxin-treated mice exhibit normal numbers of B, T and NK cells, granulocytes, monocytes and Venus- dendritic cells
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• CD8a+ dendritic cells are rapidly depleted following diphtheria toxin
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• in response to dsRNA, diphtheria-treated mice exhibit impaired CD8+ T cell response with retained cytokine and an augmented CD4+ T cell response compared with control mice
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• diphtheria toxin-treated mice exhibit impaired cross-presentation of soluble or cell-associated antigens compared with control mice
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• from ovalbumin peptide-stimulated CD8+ T cells of diphtheria-treated mice infected with L. monocytogenes
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• diphtheria-treated mice infected with L. monocytogenes exhibit reduced bacterial burden in the spleen (but not the liver), impaired expansion of antigen-specific activated T cells and reduced IFN-gamma production from ovalbumin peptide-stimulated CD8+ T cells compared with control mice
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hematopoietic system
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• CD8a+ dendritic cells are rapidly depleted following diphtheria toxin
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• in response to dsRNA, diphtheria-treated mice exhibit impaired CD8+ T cell response with retained cytokine and an augmented CD4+ T cell response compared with control mice
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