Phenotypes associated with this allele

• Allele Symbol: Jmjd1c^tm1Mtac
• Allele Name: targeted mutation 1, Makoto Tachibana
• Allele ID: MGI:5544070
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Jmjd1c^tm1Mtac/Jmjd1c^tm1Mtac	involves: C57BL/6NCrlj * CBA/JNCrlj	MGI:5544071

Genotype
MGI:5544071

cn1

• Allelic Composition: Jmjd1c^tm1Mtac/Jmjd1c^tm1Mtac
• Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

early reproductive senescence ( J:203917 )

♂ • fertility decreases at 3 months of age (7 of 8 animals) and subsequently males become infertile

cellular

abnormal spermatogonia morphology ( J:203917 )

♂ • decrease in undifferentiated spermatogonia

decreased male germ cell number ( J:203917 )

♂ • number of germ cells is normal at 2 months but significantly decreased at 4 and 8-12 months

♂ • progressive loss of germ cells both in degenerated and normal tubules

oligozoospermia ( J:203917 )

♂ • sperm content in the epididymides is indistinguishable at 2 months but significantly reduced at 8 months

increased male germ cell apoptosis ( J:203917 )

♂ • at 10 months of age, an increase in apoptotic cells is seen in germ cells from the pachytene stages to secondary spermatocytes and in spermatids

♂ • no difference in apoptotic cells in the testes at 2 months of age

reproductive system

reproductive system phenotype ( J:203917 )

♀N • females are reproductively normal

abnormal spermatogonia morphology ( J:203917 )

♂ • decrease in undifferentiated spermatogonia

decreased male germ cell number ( J:203917 )

♂ • number of germ cells is normal at 2 months but significantly decreased at 4 and 8-12 months

♂ • progressive loss of germ cells both in degenerated and normal tubules

oligozoospermia ( J:203917 )

♂ • sperm content in the epididymides is indistinguishable at 2 months but significantly reduced at 8 months

increased male germ cell apoptosis ( J:203917 )

♂ • at 10 months of age, an increase in apoptotic cells is seen in germ cells from the pachytene stages to secondary spermatocytes and in spermatids

♂ • no difference in apoptotic cells in the testes at 2 months of age

abnormal seminiferous tubule epithelium morphology ( J:203917 )

♂ • frequent occurrence of regions containing only elongating spermatids and stages lacking immature germ cells are also present

seminiferous tubule degeneration ( J:203917 )

♂ • increased abnormal regions of seminiferous tubules with age, in which the germ cell number was severely reduced

small testis ( J:203917 )

♂ • indistinguishable testes size at 1 month of age but significantly smaller at 8 months with no alteration of gross body size

decreased testis weight ( J:203917 )

♂ • weights of testes gradually decrease with age (4-12 month age)

early reproductive senescence ( J:203917 )

♂ • fertility decreases at 3 months of age (7 of 8 animals) and subsequently males become infertile

endocrine/exocrine glands

abnormal seminiferous tubule epithelium morphology ( J:203917 )

♂ • frequent occurrence of regions containing only elongating spermatids and stages lacking immature germ cells are also present

seminiferous tubule degeneration ( J:203917 )

♂ • increased abnormal regions of seminiferous tubules with age, in which the germ cell number was severely reduced

small testis ( J:203917 )

♂ • indistinguishable testes size at 1 month of age but significantly smaller at 8 months with no alteration of gross body size

decreased testis weight ( J:203917 )

♂ • weights of testes gradually decrease with age (4-12 month age)