Analysis Tools
normal phenotype
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• mice are fertile and phenotypically normal
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Allele Symbol Allele Name Allele ID |
Septin9tm2.1Emfu targeted mutation 2.1, Ernst-Martin Fuchtbauer MGI:5544189 |
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| Summary |
5 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice are fertile and phenotypically normal
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• although the abundance of SEPTIN9 is markedly reduced in sciatic nerve lysates as expected, the abundance and localization of other septin subunits expressed in PNS myelin (SEPTIN2, SEPTIN7, SEPTIN8 and SEPTIN11) are similar to those in sciatic nerve lysates of control mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• although the abundance of SEPTIN9 is markedly reduced in sciatic nerve lysates as expected, the abundance and localization of other septin subunits expressed in PNS myelin (SEPTIN2, SEPTIN7, SEPTIN8 and SEPTIN11) are similar to those in sciatic nerve lysates of control mice
• P14 sciatic nerves show no significant change in the number of normal-appearing myelinated axons; no axonal degeneration is noted and the number of myelin outfoldings is similar to that in control mice, indicating normal biogenesis of PNS myelin
• P75 sciatic nerves show similar abundance of myelin proteins (MAG, CNP, P0/MPZ, PMP22) relative to control mice
• mice exhibit normal motor nerve conduction velocity (mNCV) in sciatic nerves and normal sensory nerve conduction velocity (sNCV) in the tail nerve at 6 months of age
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| N |
• mice show no alterations in the latency of retracting a hindpaw upon a mechanical stimulus (plantar test) at P45 or in the latency of falling from an accelerating rotating rod at 2.5 months of age
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• in CD8+ T cells upon stimulation with anti-CD3 and anti-CD28 antibodies
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• partial at the DN3 to DN4 stage
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• in the thymus and lymph node
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• absolute numbers
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• general reduction in T cells
• more prominent reduction in CD8+ T cells compared with CD4+ T cells
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• reduced regulatory CD4+ T cells in the spleen
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• absolute numbers
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• reduced cytotoxic CD8+ T cells in the spleen
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• absolute numbers
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• reduced regulatory CD4+ T cells in the spleen
• reduced CD3+ T cells
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• most prominent in young mice
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• in CD8+ T cells upon stimulation with anti-CD3 and anti-CD28 antibodies
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• partial at the DN3 to DN4 stage
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• in the thymus and lymph node
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• absolute numbers
|
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• general reduction in T cells
• more prominent reduction in CD8+ T cells compared with CD4+ T cells
|
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• reduced regulatory CD4+ T cells in the spleen
|
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• absolute numbers
|
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• reduced cytotoxic CD8+ T cells in the spleen
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• absolute numbers
|
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• reduced regulatory CD4+ T cells in the spleen
• reduced CD3+ T cells
|
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• most prominent in young mice
|
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• in CD8+ T cells upon stimulation with anti-CD3 and anti-CD28 antibodies
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• in the bone marrow of pIpC-treated mice
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• in the bone marrow of pIpC-treated mice
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 06/12/2024 MGI 6.13 |
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