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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Septin9tm2.1Emfu
targeted mutation 2.1, Ernst-Martin Fuchtbauer
MGI:5544189
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Septin9tm2.1Emfu/Septin9tm2.1Emfu Not Specified MGI:5544258
cn2
 		Septin9tm2.1Emfu/Septin9tm2.1Emfu
Cnptm1(cre)Kan/Cnp+ 		involves: 129S1/Sv * 129X1/SvJ MGI:7523327
cn3
 		Septin9tm2.1Emfu/Septin9tm2.1Emfu
Tg(Dhh-cre)1Mejr/0 		involves: 129S1/Sv * FVB/N MGI:7523323
cn4
 		Septin9tm2.1Emfu/Septin9tm2.1Emfu
Tg(Lck-cre)548Jxm/0 		involves: C57BL/6 * CBA MGI:5544263
cn5
 		Septin9tm2.1Emfu/Septin9tm2.1Emfu
Tg(Mx1-cre)1Cgn/0 		involves: C57BL/6 * CBA MGI:5544265


Genotype
MGI:5544258
hm1
Allelic
Composition		 Septin9tm2.1Emfu/Septin9tm2.1Emfu
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Septin9tm2.1Emfu mutation (0 available); any Septin9 mutation (200 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:205180 )
• mice are fertile and phenotypically normal




Genotype
MGI:7523327
cn2
Allelic
Composition		 Septin9tm2.1Emfu/Septin9tm2.1Emfu
Cnptm1(cre)Kan/Cnp+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cnptm1(cre)Kan mutation (0 available); any Cnp mutation (27 available)
Septin9tm2.1Emfu mutation (0 available); any Septin9 mutation (200 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:339068 )
N
• although the abundance of SEPTIN9 is markedly reduced in sciatic nerve lysates as expected, the abundance and localization of other septin subunits expressed in PNS myelin (SEPTIN2, SEPTIN7, SEPTIN8 and SEPTIN11) are similar to those in sciatic nerve lysates of control mice




Genotype
MGI:7523323
cn3
Allelic
Composition		 Septin9tm2.1Emfu/Septin9tm2.1Emfu
Tg(Dhh-cre)1Mejr/0
Genetic
Background		 involves: 129S1/Sv * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Septin9tm2.1Emfu mutation (0 available); any Septin9 mutation (200 available)
Tg(Dhh-cre)1Mejr mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:339068 )
N
• although the abundance of SEPTIN9 is markedly reduced in sciatic nerve lysates as expected, the abundance and localization of other septin subunits expressed in PNS myelin (SEPTIN2, SEPTIN7, SEPTIN8 and SEPTIN11) are similar to those in sciatic nerve lysates of control mice
• P14 sciatic nerves show no significant change in the number of normal-appearing myelinated axons; no axonal degeneration is noted and the number of myelin outfoldings is similar to that in control mice, indicating normal biogenesis of PNS myelin
• P75 sciatic nerves show similar abundance of myelin proteins (MAG, CNP, P0/MPZ, PMP22) relative to control mice
• mice exhibit normal motor nerve conduction velocity (mNCV) in sciatic nerves and normal sensory nerve conduction velocity (sNCV) in the tail nerve at 6 months of age

behavior/neurological
behavior/neurological phenotype ( J:339068 )
N
• mice show no alterations in the latency of retracting a hindpaw upon a mechanical stimulus (plantar test) at P45 or in the latency of falling from an accelerating rotating rod at 2.5 months of age




Genotype
MGI:5544263
cn4
Allelic
Composition		 Septin9tm2.1Emfu/Septin9tm2.1Emfu
Tg(Lck-cre)548Jxm/0
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Septin9tm2.1Emfu mutation (0 available); any Septin9 mutation (200 available)
Tg(Lck-cre)548Jxm mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased T cell proliferation ( J:205027 )
• in CD8+ T cells upon stimulation with anti-CD3 and anti-CD28 antibodies
abnormal T cell differentiation ( J:205027 )
• partial at the DN3 to DN4 stage
increased double-negative T cell number ( J:205027 )
• in the thymus and lymph node
decreased T cell number ( J:205027 )
• general reduction in T cells
• more prominent reduction in CD8+ T cells compared with CD4+ T cells
decreased CD4-positive, alpha-beta T cell number ( J:205027 )
• reduced regulatory CD4+ T cells in the spleen
decreased CD8-positive, alpha-beta T cell number ( J:205027 )
• reduced cytotoxic CD8+ T cells in the spleen
decreased regulatory T cell number ( J:205027 )
• reduced regulatory CD4+ T cells in the spleen
• reduced CD3+ T cells
decreased single-positive T cell number ( J:205027 )
• most prominent in young mice

hematopoietic system
decreased T cell proliferation ( J:205027 )
• in CD8+ T cells upon stimulation with anti-CD3 and anti-CD28 antibodies
abnormal T cell differentiation ( J:205027 )
• partial at the DN3 to DN4 stage
increased double-negative T cell number ( J:205027 )
• in the thymus and lymph node
decreased T cell number ( J:205027 )
• general reduction in T cells
• more prominent reduction in CD8+ T cells compared with CD4+ T cells
decreased CD4-positive, alpha-beta T cell number ( J:205027 )
• reduced regulatory CD4+ T cells in the spleen
decreased CD8-positive, alpha-beta T cell number ( J:205027 )
• reduced cytotoxic CD8+ T cells in the spleen
decreased regulatory T cell number ( J:205027 )
• reduced regulatory CD4+ T cells in the spleen
• reduced CD3+ T cells
decreased single-positive T cell number ( J:205027 )
• most prominent in young mice

endocrine/exocrine glands

cellular
decreased T cell proliferation ( J:205027 )
• in CD8+ T cells upon stimulation with anti-CD3 and anti-CD28 antibodies




Genotype
MGI:5544265
cn5
Allelic
Composition		 Septin9tm2.1Emfu/Septin9tm2.1Emfu
Tg(Mx1-cre)1Cgn/0
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Septin9tm2.1Emfu mutation (0 available); any Septin9 mutation (200 available)
Tg(Mx1-cre)1Cgn mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased CD8-positive, alpha-beta T cell number ( J:205027 )
• in the bone marrow of pIpC-treated mice

hematopoietic system
decreased CD8-positive, alpha-beta T cell number ( J:205027 )
• in the bone marrow of pIpC-treated mice




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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory