About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gjd3tm2.1Kwi
targeted mutation 2.1, Klaus Willecke
MGI:5544288
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Gjd3tm2.1Kwi/Gjd3tm2.1Kwi involves: 129P2/OlaHsd * C57BL/6 * SJL MGI:5544302
cn2
 		Gjc1tm1Kwi/Gjc1tm1Kwi
Gjd3tm2.1Kwi/Gjd3tm2.1Kwi
Tg(Myh6-icre/ERT2)#Wet/0 		involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL MGI:5544303


Genotype
MGI:5544302
hm1
Allelic
Composition		 Gjd3tm2.1Kwi/Gjd3tm2.1Kwi
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gjd3tm2.1Kwi mutation (1 available); any Gjd3 mutation (13 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:205110 )
N
• mice are viable

cardiovascular system
cardiovascular system phenotype ( J:205110 )
N
• mice exhibit normal heart morphology, equal heart rates, P-wave duration, QRS intervals and QTc intervals without spontaneous AV block, supraventricular or ventricular ectopic beats or arrhythmia
abnormal heart electrocardiography waveform feature ( J:205110 )
• tamoxifen-treated mice exhibit shortened atria-His (AH) interval and Wenckebach periodicity compared with control mice




Genotype
MGI:5544303
cn2
Allelic
Composition		 Gjc1tm1Kwi/Gjc1tm1Kwi
Gjd3tm2.1Kwi/Gjd3tm2.1Kwi
Tg(Myh6-icre/ERT2)#Wet/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gjc1tm1Kwi mutation (1 available); any Gjc1 mutation (33 available)
Gjd3tm2.1Kwi mutation (1 available); any Gjd3 mutation (13 available)
Tg(Myh6-icre/ERT2)#Wet mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:205110 )
N
• tamoxifen-treated mice are viable

cardiovascular system
cardiovascular system phenotype ( J:205110 )
N
• tamoxifen-treated mice exhibit normal heart morphology, equal heart rates, P-wave duration, QRS intervals and QTc intervals without spontaneous AV block, supraventricular or ventricular ectopic beats or arrhythmia
abnormal heart electrocardiography waveform feature ( J:205110 )
• tamoxifen-treated mice exhibit prolonged atria-His (AH) interval and Wenckebach periodicity compared with control mice
prolonged PQ interval ( J:205110 )
• in tamoxifen-treated mice
abnormal sinoatrial node conduction ( J:205110 )
• tamoxifen-treated mice exhibit shorter sinus node recovery rate compared with control mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory