Phenotypes associated with this allele

• Allele Symbol: Wwtr1^tm1.1Eno
• Allele Name: targeted mutation 1.1, Eric N Olson
• Allele ID: MGI:5544289
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Wwtr1^tm1.1Eno/Wwtr1^+ Yap1^tm1.1Eno/Yap1^tm1.1Eno Tg(Myh6-cre)2182Mds/0	involves: 129S/SvEv * FVB/N	MGI:5544297
cn2	Wwtr1^tm1.1Eno/Wwtr1^tm1.1Eno Tg(Myh6-cre)2182Mds/0	involves: 129S/SvEv * FVB/N	MGI:5544299
cn3	Wwtr1^tm1.1Eno/Wwtr1^tm1.1Eno Yap1^tm1.1Eno/Yap1^tm1.1Eno Tg(Myh6-cre)2182Mds/0	involves: 129S/SvEv * FVB/N	MGI:5544298
cn4	Wwtr1^tm1.1Eno/Wwtr1^tm1.1Eno Yap1^tm1.1Eno/Yap1^+ Tg(Myh6-cre)2182Mds/0	involves: 129S/SvEv * FVB/N	MGI:5544296

Genotype
MGI:5544297

cn1

• Allelic Composition: Wwtr1^tm1.1Eno/Wwtr1⁺; Yap1^tm1.1Eno/Yap1^tm1.1Eno; Tg(Myh6-cre)2182Mds/0
• Genetic Background: involves: 129S/SvEv * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Cardiomyopathy in Wwtr1^tm1.2Eno/Wwtr1⁺ Yap1^tm1.1Eno/Yap1^tm1.1Eno Tg(Myh6-cre)2182Mds/0 mice

mortality/aging

postnatal lethality, complete penetrance ( J:200670 )

• die by 10 days of age

• lethality is accelerated compared to mutant mice wild type for Wwtr1

cardiovascular system

myocardium hypoplasia ( J:200670 )

• about a 60% decrease in the number of cardiomyocytes

thin myocardium ( J:200670 )

cellular

increased cardiomyocyte apoptosis ( J:200670 )

• in neonates

muscle

myocardium hypoplasia ( J:200670 )

• about a 60% decrease in the number of cardiomyocytes

thin myocardium ( J:200670 )

increased cardiomyocyte apoptosis ( J:200670 )

• in neonates

Genotype
MGI:5544299

cn2

• Allelic Composition: Wwtr1^tm1.1Eno/Wwtr1^tm1.1Eno; Tg(Myh6-cre)2182Mds/0
• Genetic Background: involves: 129S/SvEv * FVB/N

cardiovascular system

cardiovascular system phenotype ( J:200670 )

N • no obvious cardiac defects

Genotype
MGI:5544298

cn3

• Allelic Composition: Wwtr1^tm1.1Eno/Wwtr1^tm1.1Eno; Yap1^tm1.1Eno/Yap1^tm1.1Eno; Tg(Myh6-cre)2182Mds/0
• Genetic Background: involves: 129S/SvEv * FVB/N

Wwtr1^tm1.1Eno/Wwtr1^tm1.1Eno Yap1^tm1.1Eno/Yap1^tm1.1Eno Tg(Myh6-cre)2182Mds/0 mice exhibit cardiac abnormalities and Wwtr1^tm1.1Eno/Wwtr1⁺ Yap1^tm1.1Eno/Yap1^tm1.1Eno Tg(Myh6-cre)2182Mds/0 hearts show defects in proliferation and survival

mortality/aging

neonatal lethality, complete penetrance ( J:200670 )

• all die by P1

cardiovascular system

abnormal heart morphology ( J:200670 )

• severe cardiac defects

Genotype
MGI:5544296

cn4

• Allelic Composition: Wwtr1^tm1.1Eno/Wwtr1^tm1.1Eno; Yap1^tm1.1Eno/Yap1⁺; Tg(Myh6-cre)2182Mds/0
• Genetic Background: involves: 129S/SvEv * FVB/N

Cardiomyopathy in Wwtr1^tm1.2Eno/Wwtr1^tm1.2Eno Yap1^tm1.1Eno/Yap1⁺ Tg(Myh6-cre)2182Mds/0 mice

mortality/aging

premature death ( J:200670 )

• complete lethality by 33 weeks of age from heart failure

cardiovascular system

dilated cardiomyopathy ( J:200670 )

• grossly dilated at 30 weeks of age but seen as early as 8 days of age

homeostasis/metabolism

abnormal atrial thrombosis ( J:200670 )

• at 30 weeks of age

muscle

dilated cardiomyopathy ( J:200670 )

• grossly dilated at 30 weeks of age but seen as early as 8 days of age