Phenotypes associated with this allele

• Allele Symbol: Slc16a10^m1Ingm
• Allele Name: mutation 1, Ingenium Pharmaceuticals
• Allele ID: MGI:5544305
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Slc16a10^m1Ingm/Slc16a10^m1Ingm	B6.C3Fe-Slc16a10^m1Ingm	MGI:5544309

Genotype
MGI:5544309

hm1

• Allelic Composition: Slc16a10^m1Ingm/Slc16a10^m1Ingm
• Genetic Background: B6.C3Fe-Slc16a10^m1Ingm

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:205101 )

N • mice fed a normal protein diet exhibit normal glucose tolerance in an oral test

abnormal amino acid level ( J:205101 )

• mice fed a high protein diet exhibit increased L-tyrosine and L-tryptophan concentrations in the skeletal muscle and kidney and L-phenylalanine levels in the skeletal muscle compared with wild-type mice

• mice exhibit altered epithelial amino acid transport compared with wild-type mice

• mice exhibit accumulation of L-phenylalanine in intestinal everted gut sacs compared with wild-type mice

• after intra venous injection, 123I-2-I-L-phenylalanine accumulates in kidney compared with wild-type mice

abnormal circulating amino acid level ( J:205101 )

• 2-times higher L-phenylalanine, 3-times higher L-tryptophan and 7.5-times higher L-tyrosine in mice fed a normal or high protein diet

• decreased levels of glycine, L-alanine, L-methionine, L-serine, L-threonine, L-asparagine, L-glutamine, L-lysine and L-arginine in mice fed a normal or high protein diet

abnormal urine amino acid level ( J:205101 )

• decreased levels of glycine, L-alanine, L-methionine, L-serine, L-threonine, L-asparagine, L-glutamine, L-lysine and L-arginine in mice fed a normal protein diet

increased urine creatinine level ( J:205101 )

• in mice fed a high protein diet

aminoaciduria ( J:205101 )

• higher L-phenylalanine, L-tryptophan and higher L-tyrosine in mice fed a normal protein diet

• 64-times higher L-tyrosine, 95-times higher L-tryptophan and 9-times higher L-phenylalanine in mice fed a high protein diet

• 2- to 9-fold increase in many other neutral amino acids in mice fed a high protein diet

• mice fed a high protein diet exhibit enhanced aminoaciduria compared with wild-type mice

increased urine pH ( J:205101 )

• in mice fed a high protein diet

renal/urinary system

abnormal urine amino acid level ( J:205101 )

• decreased levels of glycine, L-alanine, L-methionine, L-serine, L-threonine, L-asparagine, L-glutamine, L-lysine and L-arginine in mice fed a normal protein diet

increased urine creatinine level ( J:205101 )

• in mice fed a high protein diet

aminoaciduria ( J:205101 )

• higher L-phenylalanine, L-tryptophan and higher L-tyrosine in mice fed a normal protein diet

• 64-times higher L-tyrosine, 95-times higher L-tryptophan and 9-times higher L-phenylalanine in mice fed a high protein diet

• 2- to 9-fold increase in many other neutral amino acids in mice fed a high protein diet

• mice fed a high protein diet exhibit enhanced aminoaciduria compared with wild-type mice

increased urine pH ( J:205101 )

• in mice fed a high protein diet

polyuria ( J:205101 )

• in mice fed a normal or high protein diet

behavior/neurological

behavior/neurological phenotype ( J:205101 )

N • mice exhibit normal locomotor and coordination capability

increased fluid intake ( J:205101 )

• slight increase in water intake when fed a normal protein diet

growth/size/body

growth/size/body region phenotype ( J:205101 )

N • mice exhibit normal growth after birth