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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Azi2tm1Aki
targeted mutation 1, Shizuo Akira
MGI:5544312
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Azi2tm1Aki/Azi2tm1Aki Not Specified MGI:5544314
cx2
 		Azi2tm1Aki/Azi2tm1Aki
Tbkbp1tm1Aki/Tbkbp1tm1Aki 		Not Specified MGI:5544316


Genotype
MGI:5544314
hm1
Allelic
Composition		 Azi2tm1Aki/Azi2tm1Aki
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Azi2tm1Aki mutation (0 available); any Azi2 mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:204786 )
N
• macrophages exhibit normal cytokine responses after retinoic acid-induction gene-I-like receptor (RLR) and TLR stimulation
abnormal dendritic cell differentiation ( J:204786 )
• impaired GM-CSF-derived bone marrow-derived dendritic cell differentiation
abnormal dendritic cell physiology ( J:204786 )
• GM-CSF-derived bone marrow-derived dendritic cells (GM-DCs) stimulated with TLR ligands (including poly(I:C), LPS and CpG DNA) or infection with RNA viruses (including NDV, Flu and EMCV) exhibit impaired IL6 and TNF production compared with wild-type mice
• GM-DCs stimulated with NDV infection exhibit reduced IFN-alpha production compared with wild-type cells
• stimulated GM-DCs exhibit reduced ability to stimulate CD4+ T cell proliferation and IFN-gamma production compared with wild-type cells
• GM-DCs exhibit reduced proliferation compared with wild-type mice
• however, FLT3L-derived bone marrow-derived dendritic cells (FLT3L-DC) exhibit normal ability to stimulate CD4+ T cell proliferation
decreased interferon-alpha secretion ( J:204786 )
• in GM-CSF-derived bone marrow-derived dendritic cells stimulated with NDV infection
decreased interleukin-6 secretion ( J:204786 )
• in GM-CSF-derived bone marrow-derived dendritic cells stimulated with TLR ligands (including poly(I:C), LPS and CpG DNA) or infection with RNA viruses (including NDV, Flu and EMCV)
decreased tumor necrosis factor secretion ( J:204786 )
• in GM-CSF-derived bone marrow-derived dendritic cells stimulated with TLR ligands (including poly(I:C), LPS and CpG DNA) or infection with RNA viruses (including NDV, Flu and EMCV)

hematopoietic system
abnormal dendritic cell differentiation ( J:204786 )
• impaired GM-CSF-derived bone marrow-derived dendritic cell differentiation
abnormal bone marrow cell physiology ( J:204786 )
• bone marrow cells fail to proliferate in GM-CSF culture unlike wild-type cells

respiratory system
respiratory system phenotype ( J:204786 )
N
• mice exhibit normal lung histology

cellular
abnormal dendritic cell differentiation ( J:204786 )
• impaired GM-CSF-derived bone marrow-derived dendritic cell differentiation




Genotype
MGI:5544316
cx2
Allelic
Composition		 Azi2tm1Aki/Azi2tm1Aki
Tbkbp1tm1Aki/Tbkbp1tm1Aki
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Azi2tm1Aki mutation (0 available); any Azi2 mutation (30 available)
Tbkbp1tm1Aki mutation (0 available); any Tbkbp1 mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:204786 )
N
• macrophages exhibit normal cytokine responses after retinoic acid-induction gene-I-like receptor (RLR) and TLR stimulation
abnormal dendritic cell physiology ( J:204786 )
• GM-CSF-derived bone marrow-derived dendritic cells stimulated with TLR ligands (including poly(I:C), LPS and CpG DNA) or infection with RNA viruses (including NDV, Flu and EMCV) exhibit impaired IL6 and TNF production compared with wild-type mice
• GM-CSF-derived bone marrow-derived dendritic cells stimulated with NDV infection exhibit reduced IFN-alpha production compared with wild-type cells
decreased interferon-alpha secretion ( J:204786 )
• in GM-CSF-derived bone marrow-derived dendritic cells stimulated with NDV infection
decreased interleukin-6 secretion ( J:204786 )
• in GM-CSF-derived bone marrow-derived dendritic cells stimulated with TLR ligands (including poly(I:C), LPS and CpG DNA) or infection with RNA viruses (including NDV, Flu and EMCV)
decreased tumor necrosis factor secretion ( J:204786 )
• in GM-CSF-derived bone marrow-derived dendritic cells stimulated with TLR ligands (including poly(I:C), LPS and CpG DNA) or infection with RNA viruses (including NDV, Flu and EMCV)




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory