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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Lrrc32tm1.1Hfuj
targeted mutation 1.1, Hodaka Fujii
MGI:5544317
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Lrrc32tm1.1Hfuj/Lrrc32tm1.1Hfuj
Tg(Cd4-cre)1Cwi/0 		involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NTac * DBA/2 MGI:5544318


Genotype
MGI:5544318
cn1
Allelic
Composition		 Lrrc32tm1.1Hfuj/Lrrc32tm1.1Hfuj
Tg(Cd4-cre)1Cwi/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NTac * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrrc32tm1.1Hfuj mutation (2 available); any Lrrc32 mutation (30 available)
Tg(Cd4-cre)1Cwi mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:204761 )
N
• mice exhibit normal regulatory T cell development in the thymus, maintenance in the periphery and suppression ability in vitro
abnormal regulatory T cell physiology ( J:204761 )
• regulatory T cells exhibit reduced ability to drive Th17 differentiation compared with wild-type cells

hematopoietic system
abnormal regulatory T cell physiology ( J:204761 )
• regulatory T cells exhibit reduced ability to drive Th17 differentiation compared with wild-type cells




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory