All Phenotypes m1Nish MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	m1Nish/m1Nish⁺	involves: BALB/c * C57BL/6N	MGI:5544419
ht2	m1Nish/m1Nish⁺	involves: C57BL/6N	MGI:5544420
ot3	X/m1Nish	involves: BALB/c * C57BL/6N	MGI:5544421
ot4	X/m1Nish	involves: C57BL/6N	MGI:5544422

Allelic Composition	m1Nish/m1Nish⁺
Genetic Background	involves: BALB/c * C57BL/6N

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Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:204833 )

N	• female mice exhibit normal Peyer's patch

Allelic Composition	m1Nish/m1Nish⁺
Genetic Background	involves: C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:204833 )

N	• female mice exhibit normal Peyer's patch

Allelic Composition	X/m1Nish
Genetic Background	involves: BALB/c * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

absent B cells ( J:204833 )

decreased NK cell number ( J:204833 )

absent Peyer's patches ( J:204833 )

hematopoietic system

absent B cells ( J:204833 )

decreased NK cell number ( J:204833 )

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:204833 )

decreased T cell proliferation ( J:204833 )

abnormal B cell differentiation ( J:204833 )

• arrest at the prepro-B to pro-B cell transition

• cell intrinsic failure

• however, EBF transfection restores B cell development

decreased immature B cell number ( J:204833 )

abnormal NK cell differentiation ( J:204833 )

• cell intrinsic impairment that cannot be restored by EBF transfection

decreased B cell number ( J:204833 )

decreased B-1 B cell number ( J:204833 )

absent B-1 B cells ( J:204833 )

absent B-2 B cells ( J:204833 )

absent B cells ( J:204833 )

• virtually no B (B1 and B2) cells at 12 weeks

• in castrated mice

decreased NK cell number ( J:204833 )

decreased IgG level ( J:204833 )

decreased IgM level ( J:204833 )

absent Peyer's patches ( J:204833 )

small lymph nodes ( J:204833 )

hematopoietic system

decreased T cell proliferation ( J:204833 )

abnormal B cell differentiation ( J:204833 )

• arrest at the prepro-B to pro-B cell transition

• cell intrinsic failure

• however, EBF transfection restores B cell development

decreased immature B cell number ( J:204833 )

abnormal NK cell differentiation ( J:204833 )

• cell intrinsic impairment that cannot be restored by EBF transfection

decreased B cell number ( J:204833 )

decreased B-1 B cell number ( J:204833 )

absent B-1 B cells ( J:204833 )

absent B-2 B cells ( J:204833 )

absent B cells ( J:204833 )

• virtually no B (B1 and B2) cells at 12 weeks

• in castrated mice

decreased NK cell number ( J:204833 )

decreased IgG level ( J:204833 )

decreased IgM level ( J:204833 )

cellular

decreased T cell proliferation ( J:204833 )

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