About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Capn6tm1Hiso
targeted mutation 1, Hiroyuki Sorimachi
MGI:5544425
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Capn6tm1Hiso/Capn6tm1Hiso B6.Cg-Capn6tm1Hiso MGI:5544429
ot2
 		Capn6tm1Hiso/Y B6.Cg-Capn6tm1Hiso MGI:5544430


Genotype
MGI:5544429
hm1
Allelic
Composition		 Capn6tm1Hiso/Capn6tm1Hiso
Genetic
Background		 B6.Cg-Capn6tm1Hiso
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Capn6tm1Hiso mutation (2 available); any Capn6 mutation (9 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Diameter of tongue muscle fibers is larger in Capn6tm1Hiso/Capn6tm1Hiso mice

muscle
abnormal tongue muscle morphology ( J:200747 )
• more advanced tube formation and development of striated structures at E16.5
• tongue muscle fiber diameter is increased relative to controls at E16.5
enhanced skeletal muscle regeneration ( J:200747 )
• degeneration is induced by cardiotoxin injection into the tibialis anterior, regeneration begins 4 days later
• more nuclei found in each regenerating myofiber of tibialis anterior muscle relative to heterozygous controls
• larger cross sectional area of each regenerating muscle

digestive/alimentary system
abnormal tongue muscle morphology ( J:200747 )
• more advanced tube formation and development of striated structures at E16.5
• tongue muscle fiber diameter is increased relative to controls at E16.5

craniofacial
abnormal tongue muscle morphology ( J:200747 )
• more advanced tube formation and development of striated structures at E16.5
• tongue muscle fiber diameter is increased relative to controls at E16.5

growth/size/body
abnormal tongue muscle morphology ( J:200747 )
• more advanced tube formation and development of striated structures at E16.5
• tongue muscle fiber diameter is increased relative to controls at E16.5




Genotype
MGI:5544430
ot2
Allelic
Composition		 Capn6tm1Hiso/Y
Genetic
Background		 B6.Cg-Capn6tm1Hiso
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Capn6tm1Hiso mutation (2 available); any Capn6 mutation (9 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
muscle
abnormal myogenesis ( J:200747 )
• primary culture of skeletal muscle cells induced to differentiate into myotubules using horse serum have an increased number of nuclei relative to similarly treated control cells




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory