Analysis Tools
immune system
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• mice exhibit normal endogenous IL2 secretion from activated CD4+ T cells and frequency of Foxp3+ cells
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• slightly
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• slightly
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• enhanced Th2 and Th9 in a T cell-intrinsic but regulatory T cell-extrinsic manner
• however, Th1 and Th17 differentiation are normal
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• enhanced Th2 response
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• infiltration in the lungs of untreated mice and mice in an allergic asthma model
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• infiltration in the lungs of mice in an allergic asthma model
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• slightly
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• of CD4+ T cells following stimulation with anti-CD3 and anti-CD28 antibodies in the presence or absence of exogenous IL2
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• mice develop spontaneous allergic response in the lungs unlike control mice
• in a model of allergic asthma, mice exhibit more total cells, eosinophils and lymphocytes in lung infiltrates compared with control mice
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• from lung-associated lymph node cells and splenocytes in an allergic asthma model
• from CD4+ T cells under anti-IFN-gamma or Th2 conditions
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• increased IL4+ T cells in the spleen and lung-associated lymph nodes
• increased IL4+ CD4+ T cells in lung infiltrate in an allergic asthma model
• from lung-associated lymph node cells and splenocytes in an allergic asthma model
• from CD4+ T cells under Th0, anti-IFN-gamma or Th2 conditions
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• increased IL5+ CD4+ T cells in lung infiltrate in an allergic asthma model
• from lung-associated lymph node cells and splenocytes in an allergic asthma model
• from CD4+ T cells under Th0, anti-IFN-gamma or Th2 conditions
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• increased IL9+ T cells in the spleen and lung-associated lymph nodes
• increased when cells are cultured under anti-IFN-gamma or Th9 conditions
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• at 10 months, most mice exhibit parenchymal consolidation, narrowed airways and alveoli, hyperplasia of airway smooth muscle cells and goblet cell metaplasia unlike control mice
• at 18 months, all mice exhibit more pronounced histological features than at 10 months with more severe airway obstruction due to mucus impaction and mononuclear cell infiltration unlike control mice
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respiratory system
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• at 10 months, most mice exhibit parenchymal consolidation, narrowed airways and alveoli, hyperplasia of airway smooth muscle cells and goblet cell metaplasia unlike control mice
• at 18 months, all mice exhibit more pronounced histological features than at 10 months with more severe airway obstruction due to mucus impaction and mononuclear cell infiltration unlike control mice
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• collagen accumulation in the peribronchovascular spaces
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• at 10 and 18 months
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hematopoietic system
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• of CD4+ T cells following stimulation with anti-CD3 and anti-CD28 antibodies in the presence or absence of exogenous IL2
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• slightly
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• slightly
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• enhanced Th2 and Th9 in a T cell-intrinsic but regulatory T cell-extrinsic manner
• however, Th1 and Th17 differentiation are normal
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• enhanced Th2 response
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• infiltration in the lungs of untreated mice and mice in an allergic asthma model
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• infiltration in the lungs of mice in an allergic asthma model
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endocrine/exocrine glands
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• slightly
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growth/size/body
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• slightly
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cellular
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• of CD4+ T cells following stimulation with anti-CD3 and anti-CD28 antibodies in the presence or absence of exogenous IL2
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