Phenotypes associated with this allele

• Allele Symbol: Cthrc1^tm1.1Suna
• Allele Name: targeted mutation 1.1, Sunao Takeshita
• Allele ID: MGI:5544610
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Cthrc1^tm1.1Suna/Cthrc1^tm1.1Suna Ctsk^tm1(cre)Ska/Ctsk^+	involves: 129S6/SvEvTac * C57BL/6NCrlj * C57BL/6NTac * CBA/JNCrlj	MGI:5754536
cn2	Cthrc1^tm1.1Suna/Cthrc1^tm1.1Suna Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0	involves: 129S6/SvEvTac * C57BL/6NTac * CD-1	MGI:5544624

Genotype
MGI:5754536

cn1

• Allelic Composition: Cthrc1^tm1.1Suna/Cthrc1^tm1.1Suna; Ctsk^tm1(cre)Ska/Ctsk⁺
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCrlj * C57BL/6NTac * CBA/JNCrlj

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Low bone mass in Cthrc1^tm1.1Suna/Cthrc1^tm1.1Suna Ctsk^tm1(cre)Ska/Ctsk⁺ mice

skeleton

skeleton phenotype ( J:201631 )

N • mice exhibit normal bone resorption parameters

decreased bone trabecula number ( J:201631 )

increased bone trabecular spacing ( J:201631 )

decreased trabecular bone thickness ( J:201631 )

decreased bone mass ( J:201631 )

• however, RANKL injection restores bone mass

osteoporosis ( J:201631 )

abnormal osteoid morphology ( J:201631 )

• decreased osteoid surface

decreased bone ossification ( J:201631 )

• decreased bone formation rate

Genotype
MGI:5544624

cn2

• Allelic Composition: Cthrc1^tm1.1Suna/Cthrc1^tm1.1Suna; Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac * CD-1

skeleton

skeleton phenotype ( J:201631 )

N • mice exhibit normal bone mass