Phenotypes associated with this allele

• Allele Symbol: Hand1^tm2.1Jcc
• Allele Name: targeted mutation 2.1, James C Cross
• Allele ID: MGI:5544632
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hand1^tm2.1Jcc/Hand1^tm2.1Jcc	involves: 129S1/Sv * 129X1/SvJ	MGI:5544641
ht2	Hand1^tm2.1Jcc/Hand1^+	involves: 129S1/Sv * 129X1/SvJ	MGI:5544640
ht3	Hand1^tm1Jcc/Hand1^tm2.1Jcc	involves: 129S1/Sv * 129X1/SvJ	MGI:5544639

Genotype
MGI:5544641

hm1

• Allelic Composition: Hand1^tm2.1Jcc/Hand1^tm2.1Jcc
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:202357 )

• all mice die tween E10.5 and E12.5

reproductive system

abnormal embryo implantation ( J:202357 )

• at E10.5, all mice exhibit smaller labyrinth/implantation sites compared with wild-type mice

embryo

abnormal pharyngeal arch development ( J:202357 )

• less developed

abnormal somite development ( J:202357 )

• decreased somite number at E10.5

abnormal placenta morphology ( J:202357 )

• in all mice

decreased spongiotrophoblast cell number ( J:202357 )

• reduced cells in all mice

abnormal placenta labyrinth morphology ( J:202357 )

• limited branching morphogenesis of the labyrinth

• at E10.5, all mice exhibit smaller labyrinth/implantation sites compared with wild-type mice

pale yolk sac ( J:202357 )

• in 11 of 19 mice

• however, mice exhibit normal endoderm and mesoderm in the yolk sac vasculature

abnormal placenta development ( J:202357 )

• failure of chorioallantoic attachment in 7 of 19 mice at E10.5

cardiovascular system

abnormal heart morphology ( J:202357 )

• in 10 of 19 mice at E10.5

abnormal heart development ( J:202357 )

• under-developed in some mice at E10.5

ventricular hypoplasia ( J:202357 )

• in some mice at E10.5

thin ventricular wall ( J:202357 )

• thin and less trabeculated at E10.5

craniofacial

abnormal craniofacial morphology ( J:202357 )

• in 4 of 19 mice at E10.5

nervous system

abnormal telencephalon development ( J:202357 )

• less developed

abnormal metencephalon morphology ( J:202357 )

• less developed

growth/size/body

decreased body length ( J:202357 )

• reduced crown rump length

Genotype
MGI:5544640

ht2

• Allelic Composition: Hand1^tm2.1Jcc/Hand1⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

cardiovascular system

abnormal heart morphology ( J:202357 )

• in 2 of 19 mice at E10.5

craniofacial

abnormal craniofacial morphology ( J:202357 )

• in 2 of 19 mice at E10.5

embryo

abnormal placenta development ( J:202357 )

• failure of chorioallantoic attachment in 1 of 19 mice at E10.5

Genotype
MGI:5544639

ht3

• Allelic Composition: Hand1^tm1Jcc/Hand1^tm2.1Jcc
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

mortality/aging

lethality, incomplete penetrance ( J:202357 )

• fewer than expected mice are produced

• however, surviving mice are normal

embryonic lethality during organogenesis, incomplete penetrance ( J:202357 )

• two-thirds of mice die between E10.5 and E14.5

embryo

abnormal pharyngeal arch development ( J:202357 )

• less developed

abnormal placenta morphology ( J:202357 )

• in 1 of 7 mice

decreased spongiotrophoblast cell number ( J:202357 )

• reduced cells in 1 of 7 mice

abnormal placenta labyrinth morphology ( J:202357 )

• limited branching morphogenesis of the labyrinth in 1 of 17 mice at E10.5

pale yolk sac ( J:202357 )

• in 1 of 17 mice

cardiovascular system

abnormal heart morphology ( J:202357 )

• in 7 of 17 mice at E10.5

craniofacial

abnormal craniofacial morphology ( J:202357 )

• in 4 of 17 mice at E10.5

nervous system

abnormal telencephalon development ( J:202357 )

• less developed

abnormal metencephalon morphology ( J:202357 )

• less developed