Phenotypes associated with this allele

• Allele Symbol: Gbx1^tm1Mrh
• Allele Name: targeted mutation 1, Muriel Rhinn
• Allele ID: MGI:5544724
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gbx1^tm1Mrh/Gbx1^tm1Mrh	involves: 129P2/OlaHsd * C57BL/6J	MGI:5544725

Genotype
MGI:5544725

hm1

• Allelic Composition: Gbx1^tm1Mrh/Gbx1^tm1Mrh
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Abnormal gait of a Gbx1^tm1Mrh/Gbx1^tm1Mrh mice

behavior/neurological

increased anxiety-related response ( J:201154 )

• decreased numbers of entries and spend less time in the center of the open field

impaired coordination ( J:201154 )

• in a beam walking test, the latency to cross the beam is increased in females

abnormal locomotor activation ( J:201154 )

• decrease in average speed with no significant effect on distance travelled in an open field assay

abnormal gait ( J:201154 )

• duck like gait in many mice

• many mice display lack of fluidity in movement and limping related to hyper-flexion followed by hyper-extension of one or both hind paws

• defects are first noted around P16-P17

decreased locomotor activity ( J:201154 )

• decrease in short term activity following transfer for a modified SHIRPA test

increased thermal nociceptive threshold ( J:201154 )

♂ • withdrawal latency is increased for males in a hot plate assay

nervous system

abnormal GABAergic neuron morphology ( J:201154 )

• the proportion of Gad67+ cells is decreased by 16% at E18.5 in the dorsal horn indicating a defect in GABAergic differentiation

increased nerve conduction velocity ( J:201154 )

♀ • females show increased sensory nerve conduction velocity at the level of the caudal nerve