Phenotypes associated with this allele

• Allele Symbol: Selenot^tm1.1Ics
• Allele Name: targeted mutation 1.1, Mouse Clinical Institute
• Allele ID: MGI:5544732
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Selenot^tm1.1Ics/Selenot^tm1.1Ics Tg(Ins2-cre)25Mgn/0	involves: 129S2/SvPas * C57BL/6 * C57BL/6J * DBA	MGI:5544757

Genotype
MGI:5544757

cn1

• Allelic Composition: Selenot^tm1.1Ics/Selenot^tm1.1Ics; Tg(Ins2-cre)25Mgn/0
• Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6J * DBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:203279 )

N • mice exhibit normal insulin sensitivity

decreased insulin secretion ( J:203279 )

• in the pancreas

increased circulating glucose level ( J:203279 )

decreased circulating insulin level ( J:203279 )

• after glucose load

• however, basal levels are normal

impaired glucose tolerance ( J:203279 )

endocrine/exocrine glands

increased pancreatic islet number ( J:203279 )

• increased number of small islets

• however, islet mass is normal

small pancreatic islets ( J:203279 )

• however, islet mass is normal

decreased insulin secretion ( J:203279 )

• in the pancreas