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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Adgra2tm2.1Vlcg
targeted mutation 2.1, Velocigene
MGI:5544776
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Adgra2tm2.1Vlcg/Adgra2tm2.1Vlcg involves: 129S6/SvEvTac * C57BL/6NTac MGI:5546223
ht2
 		Adgra2tm1.1Vlcg/Adgra2tm2.1Vlcg involves: 129S6/SvEvTac * C57BL/6NTac MGI:5546224
cn3
 		Adgra2tm1.1Vlcg/Adgra2tm2.1Vlcg
Gt(ROSA)26Sortm3.1(cre/ERT2)Vlcg/Gt(ROSA)26Sor+ 		involves: 129S6/SvEvTac * C57BL/6NTac MGI:5546225


Genotype
MGI:5546223
hm1
Allelic
Composition		 Adgra2tm2.1Vlcg/Adgra2tm2.1Vlcg
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adgra2tm2.1Vlcg mutation (0 available); any Adgra2 mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype




Genotype
MGI:5546224
ht2
Allelic
Composition		 Adgra2tm1.1Vlcg/Adgra2tm2.1Vlcg
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adgra2tm1.1Vlcg mutation (0 available); any Adgra2 mutation (43 available)
Adgra2tm2.1Vlcg mutation (0 available); any Adgra2 mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype




Genotype
MGI:5546225
cn3
Allelic
Composition		 Adgra2tm1.1Vlcg/Adgra2tm2.1Vlcg
Gt(ROSA)26Sortm3.1(cre/ERT2)Vlcg/Gt(ROSA)26Sor+
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adgra2tm1.1Vlcg mutation (0 available); any Adgra2 mutation (43 available)
Adgra2tm2.1Vlcg mutation (0 available); any Adgra2 mutation (43 available)
Gt(ROSA)26Sortm3.1(cre/ERT2)Vlcg mutation (0 available); any Gt(ROSA)26Sor mutation (993 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal brain vasculature morphology ( J:200671 )
• mice treated with tamoxifen at E8 exhibit abnormal ventral forebrain vasculature at E12.5 compared with control mice
• tamoxifen-treated mice exhibit similar but less severe phenotypes compared with Gpr124tm1.1Vlcg homozygotes

nervous system
abnormal brain vasculature morphology ( J:200671 )
• mice treated with tamoxifen at E8 exhibit abnormal ventral forebrain vasculature at E12.5 compared with control mice
• tamoxifen-treated mice exhibit similar but less severe phenotypes compared with Gpr124tm1.1Vlcg homozygotes




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory