Phenotypes associated with this allele

• Allele Symbol: Tg(AMELX-cre)A1Kul
• Allele Name: transgene insertion A1, Ashok B Kulkarni
• Allele ID: MGI:5544787
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Tgfbr2^tm1Karl/Tgfbr2^tm1Karl Tg(AMELX-cre)A1Kul/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/NCr	MGI:5544817

Genotype
MGI:5544817

cn1

• Allelic Composition: Tgfbr2^tm1Karl/Tgfbr2^tm1Karl; Tg(AMELX-cre)A1Kul/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/NCr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

craniofacial

abnormal molar morphology ( J:205404 )

• x-ray analysis reveals dental attrition of the molar cusps at 3 months

abnormal enamel morphology ( J:205404 )

• mandibular molars show a flattened enamel layer in 3-month old animals

abnormal enamel mineralization ( J:205404 )

• flattened enamel layer suggests that the molar enamel has a mineralization defect resulting in increased attrition with age

• a >2-fold decrease in molar-mineralized enamel volume is observed at 1 and 2 months compared to controls

• hypomineralized enamel can not be clearly separated from bone and dentin

• molar outer aprismatic enamel shows irregular organization with increased porosity

• enamel crystallites are thin and prismatic showing disorganization

• in mutants ameloblast morphology appears normal in teeth

reduced enamel thickness ( J:205404 )

• enamel is thinner along molar cusps in 3-month old animals

abnormal tooth attrition ( J:205404 )

• enamel mineralization defect results in increased attrition with age

skeleton

abnormal molar morphology ( J:205404 )

• x-ray analysis reveals dental attrition of the molar cusps at 3 months

abnormal enamel morphology ( J:205404 )

• mandibular molars show a flattened enamel layer in 3-month old animals

abnormal enamel mineralization ( J:205404 )

• flattened enamel layer suggests that the molar enamel has a mineralization defect resulting in increased attrition with age

• a >2-fold decrease in molar-mineralized enamel volume is observed at 1 and 2 months compared to controls

• hypomineralized enamel can not be clearly separated from bone and dentin

• molar outer aprismatic enamel shows irregular organization with increased porosity

• enamel crystallites are thin and prismatic showing disorganization

• in mutants ameloblast morphology appears normal in teeth

reduced enamel thickness ( J:205404 )

• enamel is thinner along molar cusps in 3-month old animals

abnormal tooth attrition ( J:205404 )

• enamel mineralization defect results in increased attrition with age

growth/size/body

abnormal molar morphology ( J:205404 )

• x-ray analysis reveals dental attrition of the molar cusps at 3 months

abnormal enamel morphology ( J:205404 )

• mandibular molars show a flattened enamel layer in 3-month old animals

abnormal enamel mineralization ( J:205404 )

• flattened enamel layer suggests that the molar enamel has a mineralization defect resulting in increased attrition with age

• a >2-fold decrease in molar-mineralized enamel volume is observed at 1 and 2 months compared to controls

• hypomineralized enamel can not be clearly separated from bone and dentin

• molar outer aprismatic enamel shows irregular organization with increased porosity

• enamel crystallites are thin and prismatic showing disorganization

• in mutants ameloblast morphology appears normal in teeth

reduced enamel thickness ( J:205404 )

• enamel is thinner along molar cusps in 3-month old animals

abnormal tooth attrition ( J:205404 )

• enamel mineralization defect results in increased attrition with age