Phenotypes associated with this allele

• Allele Symbol: Entpd2^tm1Srob
• Allele Name: targeted mutation 1, Simon C Robson
• Allele ID: MGI:5545886
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Entpd2^tm1Srob/Entpd2^tm1Srob	B6.129-Entpd2^tm1Srob	MGI:5545888

Genotype
MGI:5545888

hm1

• Allelic Composition: Entpd2^tm1Srob/Entpd2^tm1Srob
• Genetic Background: B6.129-Entpd2^tm1Srob

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

taste/olfaction

abnormal gustatory papilla taste bud morphology ( J:200972 )

• overall, circumvallate papilla size is approximately 15% smaller

• however, size and number of taste buds are similar to controls

abnormal gustatory system physiology ( J:200972 )

• elevated levels of ATP in the epithelium of circumvallate taste papillae

• stimulation of the apical membrane with a mixture of bitter tastants fails to evoke ATP release

abnormal taste sensitivity ( J:200972 )

• decreased neural responses to taste stimuli

nervous system

abnormal nerve fiber response ( J:200972 )

• responses of the chorda tympani nerve to sucrose and monosodium glutamate (MSG) with amiloride are significantly decreased

• responses of the glossopharyngeal nerve to sucrose, monosodium glutamate (MSG) with amiloride, HCL, citric acid, NaCl, quinine, and NH4Cl are significantly decreased

growth/size/body

abnormal gustatory papilla taste bud morphology ( J:200972 )

• overall, circumvallate papilla size is approximately 15% smaller

• however, size and number of taste buds are similar to controls

craniofacial

abnormal gustatory papilla taste bud morphology ( J:200972 )

• overall, circumvallate papilla size is approximately 15% smaller

• however, size and number of taste buds are similar to controls

digestive/alimentary system

abnormal gustatory papilla taste bud morphology ( J:200972 )

• overall, circumvallate papilla size is approximately 15% smaller

• however, size and number of taste buds are similar to controls