All Phenotypes Gt(ROSA)26Sor<tm3.1(cre/ERT2)Vlcg> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Gt(ROSA)26Sor^{tm3.1(cre/ERT2)Vlcg}
targeted mutation 3.1, Velocigene
MGI:5545927

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Acvr1^tm2.1Vlcg/Acvr1⁺ Gt(ROSA)26Sor^{tm3.1(cre/ERT2)Vlcg}/Gt(ROSA)26Sor⁺	involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6NTac	MGI:5825038
cn2	Dll4^tm2.1Vlcg/Dll4^tm2.1Vlcg Gt(ROSA)26Sor^{tm3.1(cre/ERT2)Vlcg}/Gt(ROSA)26Sor⁺	involves: 129S6/SvEvTac * C57BL/6NTac	MGI:5546217
cn3	Dll4^tm3.1Vlcg/Dll4⁺ Gt(ROSA)26Sor^{tm3.1(cre/ERT2)Vlcg}/Gt(ROSA)26Sor⁺	involves: 129S6/SvEvTac * C57BL/6NTac	MGI:5546218
cn4	Adgra2^tm1.1Vlcg/Adgra2^tm2.1Vlcg Gt(ROSA)26Sor^{tm3.1(cre/ERT2)Vlcg}/Gt(ROSA)26Sor⁺	involves: 129S6/SvEvTac * C57BL/6NTac	MGI:5546225
cn5	Drosha^tm1.1Vlcg/Drosha^tm3Vlcg Gt(ROSA)26Sor^{tm3.1(cre/ERT2)Vlcg}/Gt(ROSA)26Sor⁺	involves: 129S6/SvEvTac * C57BL/6NTac	MGI:5546236

Allelic Composition	Acvr1^tm2.1Vlcg/Acvr1⁺ Gt(ROSA)26Sor^{tm3.1(cre/ERT2)Vlcg}/Gt(ROSA)26Sor⁺
Genetic Background	involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6NTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Acvr1^tm2.1Vlcg mutation (0 available); any Acvr1 mutation (44 available)
Gt(ROSA)26Sor^{tm3.1(cre/ERT2)Vlcg} mutation (0 available); any Gt(ROSA)26Sor mutation (993 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

increased bone ossification ( J:234069 )

• as early as 2 weeks, tamoxifen-treated mice exhibit progressive, heterotopic ossification (HO) in the sternum, caudal vertebrae, hip joint and hindlimb resulting in fusion between the heterotropic bone and native skeletal elements

• mature heterotropic bone contain bone marrow and resemble normal bone

• however, treatment with broad-acting BMP and activin blockers ACVR2A-Fc and ACVR2B-Fc, alone or in combination, inhibits or ameliorates HO phenotype

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
fibrodysplasia ossificans progressiva		DOID:13374	OMIM:135100	J:234069

Allelic Composition	Dll4^tm2.1Vlcg/Dll4^tm2.1Vlcg Gt(ROSA)26Sor^{tm3.1(cre/ERT2)Vlcg}/Gt(ROSA)26Sor⁺
Genetic Background	involves: 129S6/SvEvTac * C57BL/6NTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dll4^tm2.1Vlcg mutation (0 available); any Dll4 mutation (27 available)
Gt(ROSA)26Sor^{tm3.1(cre/ERT2)Vlcg} mutation (0 available); any Gt(ROSA)26Sor mutation (993 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal retina vasculature morphology ( J:200671 )

• abrogated maturation in mice treated with tamoxifen at P5

vision/eye

abnormal retina vasculature morphology ( J:200671 )

• abrogated maturation in mice treated with tamoxifen at P5

Allelic Composition	Dll4^tm3.1Vlcg/Dll4⁺ Gt(ROSA)26Sor^{tm3.1(cre/ERT2)Vlcg}/Gt(ROSA)26Sor⁺
Genetic Background	involves: 129S6/SvEvTac * C57BL/6NTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dll4^tm3.1Vlcg mutation (0 available); any Dll4 mutation (27 available)
Gt(ROSA)26Sor^{tm3.1(cre/ERT2)Vlcg} mutation (0 available); any Gt(ROSA)26Sor mutation (993 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:200671 )

Allelic Composition	Adgra2^tm1.1Vlcg/Adgra2^tm2.1Vlcg Gt(ROSA)26Sor^{tm3.1(cre/ERT2)Vlcg}/Gt(ROSA)26Sor⁺
Genetic Background	involves: 129S6/SvEvTac * C57BL/6NTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adgra2^tm1.1Vlcg mutation (0 available); any Adgra2 mutation (43 available)
Adgra2^tm2.1Vlcg mutation (0 available); any Adgra2 mutation (43 available)
Gt(ROSA)26Sor^{tm3.1(cre/ERT2)Vlcg} mutation (0 available); any Gt(ROSA)26Sor mutation (993 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal brain vasculature morphology ( J:200671 )

• mice treated with tamoxifen at E8 exhibit abnormal ventral forebrain vasculature at E12.5 compared with control mice

• tamoxifen-treated mice exhibit similar but less severe phenotypes compared with Gpr124^tm1.1Vlcg homozygotes

nervous system

abnormal brain vasculature morphology ( J:200671 )

• mice treated with tamoxifen at E8 exhibit abnormal ventral forebrain vasculature at E12.5 compared with control mice

• tamoxifen-treated mice exhibit similar but less severe phenotypes compared with Gpr124^tm1.1Vlcg homozygotes

Allelic Composition	Drosha^tm1.1Vlcg/Drosha^tm3Vlcg Gt(ROSA)26Sor^{tm3.1(cre/ERT2)Vlcg}/Gt(ROSA)26Sor⁺
Genetic Background	involves: 129S6/SvEvTac * C57BL/6NTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Drosha^tm1.1Vlcg mutation (0 available); any Drosha mutation (96 available)
Drosha^tm3Vlcg mutation (0 available); any Drosha mutation (96 available)
Gt(ROSA)26Sor^{tm3.1(cre/ERT2)Vlcg} mutation (0 available); any Gt(ROSA)26Sor mutation (993 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:200671 )

N	• tamoxifen-treated mice are born and survive

growth/size/body

decreased body size ( J:200671 )

• tamoxifen-treated mice are runted

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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