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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Wfikkn2tm1.1Sjl
targeted mutation 1.1, Sejin Lee
MGI:5546173
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Wfikkn2tm1.1Sjl/Wfikkn2tm1.1Sjl involves: 129 * C57BL/6 MGI:5546331
cx2
 		Wfikkn1tm1.1Sjl/Wfikkn1tm1.1Sjl
Wfikkn2tm1.1Sjl/Wfikkn2tm1.1Sjl 		involves: 129 * C57BL/6 MGI:5546332
cx3
 		Gdf11tm1Sjl/Gdf11tm1Sjl
Wfikkn2tm1.1Sjl/Wfikkn2tm1.1Sjl 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:5546333


Genotype
MGI:5546331
hm1
Allelic
Composition		 Wfikkn2tm1.1Sjl/Wfikkn2tm1.1Sjl
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Wfikkn2tm1.1Sjl mutation (0 available); any Wfikkn2 mutation (20 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Skeletal muscle abnormalities in Wfikkn2tm1.1Sjl/Wfikkn2tm1.1Sjl and Wfikkn1tm1.1Sjl/Wfikkn1tm1.1Sjl mice

limbs/digits/tail
abnormal limb muscle morphology ( J:201148 )
• the triceps is least effected with a 5% decrease in weight
decreased quadriceps weight ( J:201148 )
• the quadriceps is most the most effected muscle with a 12% in weight

muscle
abnormal limb muscle morphology ( J:201148 )
• the triceps is least effected with a 5% decrease in weight
decreased quadriceps weight ( J:201148 )
• the quadriceps is most the most effected muscle with a 12% in weight
decreased skeletal muscle weight ( J:201148 )
• decrease of 5-12% in muscle weight in males at 10 weeks of age
abnormal skeletal muscle fiber type ratio ( J:201148 )
• seems to be a shift in fiber type from fast glycolytic type IIb fibers to fast oxidative type IIa fibers in the gastrocnemius muscle
impaired skeletal muscle regeneration ( J:201148 )
• impaired regeneration following cardiotoxin induced injury of the gastrocnemius muscle

skeleton
skeleton phenotype ( J:201148 )
N
• no skeletal defects




Genotype
MGI:5546332
cx2
Allelic
Composition		 Wfikkn1tm1.1Sjl/Wfikkn1tm1.1Sjl
Wfikkn2tm1.1Sjl/Wfikkn2tm1.1Sjl
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Wfikkn1tm1.1Sjl mutation (0 available); any Wfikkn1 mutation (15 available)
Wfikkn2tm1.1Sjl mutation (0 available); any Wfikkn2 mutation (20 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Impaired muscle regeneration in Wfikkn2tm1.1Sjl/Wfikkn2tm1.1Sjl, Wfikkn1tm1.1Sjl/Wfikkn1tm1.1Sjl, and double mutant mice after cardiotoxin injury

muscle
impaired skeletal muscle regeneration ( J:201148 )
• impaired regeneration following cardiotoxin induced injury of the gastrocnemius muscle

skeleton
abnormal axial skeleton morphology ( J:201148 )
• patterning defects are similar to mice homozygous for Wfikkn1tm1.1Sjl alone




Genotype
MGI:5546333
cx3
Allelic
Composition		 Gdf11tm1Sjl/Gdf11tm1Sjl
Wfikkn2tm1.1Sjl/Wfikkn2tm1.1Sjl
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gdf11tm1Sjl mutation (0 available); any Gdf11 mutation (13 available)
Wfikkn2tm1.1Sjl mutation (0 available); any Wfikkn2 mutation (20 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Craniofacial defects in Wfikkn2tm1.1Sjl/Wfikkn2tm1.1Sjl Gdf11tm1Sjl/Gdf11tm1Sjl mice

skeleton
abnormal axial skeleton morphology ( J:201148 )
• anteriorly directed homeotic transformation
abnormal sternocostal joint morphology ( J:201148 )
• have 10 or 11 attached ribs
increased rib number ( J:201148 )
• have 10 or 11 attached ribs
increased thoracic vertebrae number ( J:201148 )
• most have 18 thoracic vertebrae
abnormal cervical vertebrae morphology ( J:201148 )
• rarely the anterior tuberculum is on C7
increased lumbar vertebrae number ( J:201148 )
• have 8, 8/9 or 9 lumbar vertebrae

craniofacial
cleft palate ( J:201148 )
• in all mice

digestive/alimentary system
cleft palate ( J:201148 )
• in all mice

growth/size/body
cleft palate ( J:201148 )
• in all mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory