All Phenotypes Wfikkn1<tm1.1Sjl> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Wfikkn1^tm1.1Sjl
targeted mutation 1.1, Sejin Lee
MGI:5546193

Summary

6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Wfikkn1^tm1.1Sjl/Wfikkn1^tm1.1Sjl	involves: 129 * C57BL/6	MGI:5546334
cx2	Wfikkn1^tm1.1Sjl/Wfikkn1^tm1.1Sjl Wfikkn2^tm1.1Sjl/Wfikkn2^tm1.1Sjl	involves: 129 * C57BL/6	MGI:5546332
cx3	Gdf11^tm1Sjl/Gdf11^tm1Sjl Wfikkn1^tm1.1Sjl/Wfikkn1^tm1.1Sjl	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:5546335
cx4	Fst^tm1Zuk/Fst^tm1Zuk Wfikkn1^tm1.1Sjl/Wfikkn1^tm1.1Sjl	involves: 129S7/SvEvBrd * C57BL/6	MGI:5546336
cx5	Fst^tm1Zuk/Fst⁺ Wfikkn1^tm1.1Sjl/Wfikkn1^tm1.1Sjl	involves: 129S7/SvEvBrd * C57BL/6	MGI:5546337
cx6	Fst^tm1Zuk/Fst^tm1Zuk Wfikkn1^tm1.1Sjl/Wfikkn1⁺	involves: 129S7/SvEvBrd * C57BL/6	MGI:5546338

Allelic Composition	Wfikkn1^tm1.1Sjl/Wfikkn1^tm1.1Sjl
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Wfikkn1^tm1.1Sjl mutation (0 available); any Wfikkn1 mutation (15 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Axial skeleton patterning defects in Wfikkn1^tm1.1Sjl/Wfikkn1^tm1.1Sjl, Wfikkn1^tm1.1Sjl/Wfikkn1^tm1.1Sjl Fst^tm1Zuk/Fst^tm1Zuk, Gdf11^tm1Sjl/Gdf11⁺ and Gdf11^tm1Sjl/Gdf11^tm1Sjl mice.

limbs/digits/tail

abnormal limb muscle morphology ( J:201148 )

• the triceps is least effected with a 7.1% decrease in weight

decreased quadriceps weight ( J:201148 )

• the quadriceps is most the most effected muscle with a 8.6% in weight

skeleton

abnormal axial skeleton morphology ( J:201148 )

• posteriorly directed homeotic transformations throughout the axial skeleton with incomplete penetrance

• partial or complete loss of one lumbar segment in approximately 12% of mice

abnormal cervical rib ( J:201148 )

• rarely a supernumerary rib arising from the 7th cervical vertebra is seen

decreased rib number ( J:201148 )

• almost 90% of mice have at least 1 truncated or absent 13th rib

• over 40% of mice lack both 13th ribs

increased rib number ( J:201148 )

• rarely a supernumerary rib arising from the 7th cervical vertebra is seen

thoracic vertebral transformation ( J:201148 )

• partial penetrance of transformation of the 13th thoracic segment into a lumbar segment

abnormal cervical vertebrae morphology ( J:201148 )

• rarely the anterior tuberculum is shifted from C6 to C5

muscle

abnormal limb muscle morphology ( J:201148 )

• the triceps is least effected with a 7.1% decrease in weight

decreased quadriceps weight ( J:201148 )

• the quadriceps is most the most effected muscle with a 8.6% in weight

decreased skeletal muscle weight ( J:201148 )

• decrease of 6-9% in muscle weight in males at 10 weeks of age

abnormal skeletal muscle fiber type ratio ( J:201148 )

• seems to be a shift in fiber type from fast glycolytic type IIb fibers to fast oxidative type IIa fibers in the gastrocnemius muscle

impaired skeletal muscle regeneration ( J:201148 )

• impaired regeneration following cardiotoxin induced injury of the gastrocnemius muscle

Allelic Composition	Wfikkn1^tm1.1Sjl/Wfikkn1^tm1.1Sjl Wfikkn2^tm1.1Sjl/Wfikkn2^tm1.1Sjl
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Wfikkn1^tm1.1Sjl mutation (0 available); any Wfikkn1 mutation (15 available)
Wfikkn2^tm1.1Sjl mutation (0 available); any Wfikkn2 mutation (20 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Impaired muscle regeneration in Wfikkn2^tm1.1Sjl/Wfikkn2^tm1.1Sjl, Wfikkn1^tm1.1Sjl/Wfikkn1^tm1.1Sjl, and double mutant mice after cardiotoxin injury

muscle

impaired skeletal muscle regeneration ( J:201148 )

• impaired regeneration following cardiotoxin induced injury of the gastrocnemius muscle

skeleton

abnormal axial skeleton morphology ( J:201148 )

• patterning defects are similar to mice homozygous for Wfikkn1^tm1.1Sjl alone

Allelic Composition	Gdf11^tm1Sjl/Gdf11^tm1Sjl Wfikkn1^tm1.1Sjl/Wfikkn1^tm1.1Sjl
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gdf11^tm1Sjl mutation (0 available); any Gdf11 mutation (11 available)
Wfikkn1^tm1.1Sjl mutation (0 available); any Wfikkn1 mutation (15 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

abnormal axial skeleton morphology ( J:201148 )

• phenotype of anteriorly directed homeotic transformations is indistinguishable from mice homozygous for Gdf11^tm1Sjl alone

increased rib number ( J:201148 )

• have either 10 or 11 attached ribs

increased thoracic vertebrae number ( J:201148 )

• all have 18 thoracic vertebrae

increased lumbar vertebrae number ( J:201148 )

• have between 7 and 8 lumbar vertebrae

digestive/alimentary system

cleft palate ( J:201148 )

• in most mice

craniofacial

cleft palate ( J:201148 )

• in most mice

growth/size/body

cleft palate ( J:201148 )

• in most mice

Allelic Composition	Fst^tm1Zuk/Fst^tm1Zuk Wfikkn1^tm1.1Sjl/Wfikkn1^tm1.1Sjl
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fst^tm1Zuk mutation (2 available); any Fst mutation (18 available)
Wfikkn1^tm1.1Sjl mutation (0 available); any Wfikkn1 mutation (15 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Axial skeleton patterning defects in Wfikkn1^tm1.1Sjl/Wfikkn1^tm1.1Sjl, Wfikkn1^tm1.1Sjl/Wfikkn1^tm1.1Sjl Fst^tm1Zuk/Fst^tm1Zuk, Gdf11^tm1Sjl/Gdf11⁺ and Gdf11^tm1Sjl/Gdf11^tm1Sjl mice.

skeleton

abnormal cervical rib ( J:201148 )

• mice have cervical ribs on one side or both sides

decreased rib number ( J:201148 )

• both 13th ribs are missing

• most mice have 6 or 6.5 attached ribs

increased rib number ( J:201148 )

• mice have cervical ribs on one side or both sides

decreased thoracic vertebrae number ( J:201148 )

• all mice have only 12 thoracic vertebrae

decreased lumbar vertebrae number ( J:201148 )

• one mouse had only 4 lumbar vertebrae

Allelic Composition	Fst^tm1Zuk/Fst⁺ Wfikkn1^tm1.1Sjl/Wfikkn1^tm1.1Sjl
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Axial skeleton patterning defects in Wfikkn1^tm1.1Sjl/Wfikkn1^tm1.1Sjl, Wfikkn1^tm1.1Sjl/Wfikkn1^tm1.1Sjl Fst^tm1Zuk/Fst^tm1Zuk, Gdf11^tm1Sjl/Gdf11⁺ and Gdf11^tm1Sjl/Gdf11^tm1Sjl mice.

skeleton

abnormal cervical rib ( J:201148 )

• cervical ribs are seen on one or both sides in most mice

decreased rib number ( J:201148 )

• over 90% of mice are missing both 13th ribs

increased rib number ( J:201148 )

• cervical ribs are seen on one or both sides in most mice

decreased thoracic vertebrae number ( J:201148 )

• most mice have 12 thoracic vertebrae

increased lumbar vertebrae number ( J:201148 )

• 25% of mice have 6/7 lumbar vertebrae

Allelic Composition	Fst^tm1Zuk/Fst^tm1Zuk Wfikkn1^tm1.1Sjl/Wfikkn1⁺
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

decreased rib number ( J:201148 )

• 50% of mice have only 12 thoracic vertebrae

decreased thoracic vertebrae number ( J:201148 )

• in 50% of mice the 13th pair of ribs consist of one anlage and the other is absent and in the other 50% of mice both 13th ribs are missing

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