All Phenotypes Nr4a1<tm1Pcn> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Nr4a1^tm1Pcn
targeted mutation 1, Pierre Chambon
MGI:5546594

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Nr4a1^tm1Pcn/Nr4a1^tm1Pcn Tg(Cr2-cre)3Cgn/0	involves: 129	MGI:6717462
cn2	Cd79a^tm1(cre)Reth/Cd79a⁺ Nr4a1^tm1Pcn/Nr4a1^tm1Pcn	involves: 129 * BALB/c	MGI:6717461
cn3	Cd79a^tm1(cre)Reth/Cd79a⁺ Nr4a1^tm1Pcn/Nr4a1^tm1Pcn Nr4a3^em1Juz/Nr4a3^em1Juz	involves: 129 * BALB/c * C57BL/6	MGI:6717460
cn4	Nr4a1^tm1Pcn/Nr4a1^tm1Pcn Foxp3^{tm4(YFP/icre)Ayr}/Foxp3⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:5546602

Allelic Composition	Nr4a1^tm1Pcn/Nr4a1^tm1Pcn Tg(Cr2-cre)3Cgn/0
Genetic Background	involves: 129

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr4a1^tm1Pcn mutation (0 available); any Nr4a1 mutation (39 available)
Tg(Cr2-cre)3Cgn mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

increased B cell proliferation ( J:306652 )

• greater proliferation of CD45.2+ B cells when co-cultured for 72 hours with congenically marked wild-type CD45.1+ lymphocytes and anti-immunoglobulin M (anti-IgM)

hematopoietic system

increased B cell proliferation ( J:306652 )

• greater proliferation of CD45.2+ B cells when co-cultured for 72 hours with congenically marked wild-type CD45.1+ lymphocytes and anti-immunoglobulin M (anti-IgM)

immune system

increased B cell proliferation ( J:306652 )

• greater proliferation of CD45.2+ B cells when co-cultured for 72 hours with congenically marked wild-type CD45.1+ lymphocytes and anti-immunoglobulin M (anti-IgM)

Allelic Composition	Cd79a^tm1(cre)Reth/Cd79a⁺ Nr4a1^tm1Pcn/Nr4a1^tm1Pcn
Genetic Background	involves: 129 * BALB/c

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79a^tm1(cre)Reth mutation (3 available); any Cd79a mutation (24 available)
Nr4a1^tm1Pcn mutation (0 available); any Nr4a1 mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

increased B cell proliferation ( J:306652 )

• greater proliferation of CD45.2+ B cells when co-cultured for 72 hours with congenically marked wild-type CD45.1+ lymphocytes and anti-immunoglobulin M (anti-IgM)

hematopoietic system

increased B cell proliferation ( J:306652 )

• greater proliferation of CD45.2+ B cells when co-cultured for 72 hours with congenically marked wild-type CD45.1+ lymphocytes and anti-immunoglobulin M (anti-IgM)

immune system

increased B cell proliferation ( J:306652 )

• greater proliferation of CD45.2+ B cells when co-cultured for 72 hours with congenically marked wild-type CD45.1+ lymphocytes and anti-immunoglobulin M (anti-IgM)

Allelic Composition	Cd79a^tm1(cre)Reth/Cd79a⁺ Nr4a1^tm1Pcn/Nr4a1^tm1Pcn Nr4a3^em1Juz/Nr4a3^em1Juz
Genetic Background	involves: 129 * BALB/c * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

decreased B cell apoptosis ( J:306652 )

• greater survival of CD45.2+ B cells when co-cultured for 72 hours with congenically marked wild-type CD45.1+ B cells and anti-immunoglobulin M (anti-IgM)

increased B cell proliferation ( J:306652 )

• greater proliferation of CD45.2+ B cells when co-cultured for 72 hours with congenically marked wild-type CD45.1+ B cells and anti-immunoglobulin M (anti-IgM)

hematopoietic system

decreased B cell apoptosis ( J:306652 )

• greater survival of CD45.2+ B cells when co-cultured for 72 hours with congenically marked wild-type CD45.1+ B cells and anti-immunoglobulin M (anti-IgM)

increased B cell proliferation ( J:306652 )

• greater proliferation of CD45.2+ B cells when co-cultured for 72 hours with congenically marked wild-type CD45.1+ B cells and anti-immunoglobulin M (anti-IgM)

immune system

immune system phenotype ( J:306652 )

N	• normal T cell and B cell development and homeostasis

decreased B cell apoptosis ( J:306652 )

• greater survival of CD45.2+ B cells when co-cultured for 72 hours with congenically marked wild-type CD45.1+ B cells and anti-immunoglobulin M (anti-IgM)

increased B cell proliferation ( J:306652 )

• greater proliferation of CD45.2+ B cells when co-cultured for 72 hours with congenically marked wild-type CD45.1+ B cells and anti-immunoglobulin M (anti-IgM)

Allelic Composition	Nr4a1^tm1Pcn/Nr4a1^tm1Pcn Foxp3^{tm4(YFP/icre)Ayr}/Foxp3⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxp3^{tm4(YFP/icre)Ayr} mutation (2 available); any Foxp3 mutation (58 available)
Nr4a1^tm1Pcn mutation (0 available); any Nr4a1 mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:205658 )

N	• the ratio of YFP+/YFP- regulatory T cells is normal

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