Phenotypes associated with this allele

• Allele Symbol: Plcd1^tm1.1Kfu
• Allele Name: targeted mutation 1.1, Kiyoko Fukami
• Allele ID: MGI:5546649
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Plcd1^tm1.1Kfu/Plcd1^tm1.1Kfu Tg(KRT14-cre)1Amc/0	involves: C57BL/6 * C57BL/6JJcl * CBA	MGI:5547367

Genotype
MGI:5547367

cn1

• Allelic Composition: Plcd1^tm1.1Kfu/Plcd1^tm1.1Kfu; Tg(KRT14-cre)1Amc/0
• Genetic Background: involves: C57BL/6 * C57BL/6JJcl * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased granulocyte number ( J:205633 )

decreased B cell number ( J:205633 )

• in the bone marrow

increased NK T cell number ( J:205633 )

• 1.7-fold in CD3+ T cells

increased circulating interleukin-17 level ( J:205633 )

enlarged inguinal lymph nodes ( J:205633 )

• with increased cell number

increased susceptibility to type IV hypersensitivity reaction ( J:205633 )

• more prominent ear swelling with exaggerated edema and severe inflammatory cell infiltration

• however, IL17 neutralization abrogates exaggerated swelling

increased interleukin-17 secretion ( J:205633 )

• 6-times increase in IL17+ cells in the inguinal lymph nodes

homeostasis/metabolism

increased circulating interleukin-17 level ( J:205633 )

hematopoietic system

decreased erythrocyte cell number ( J:205633 )

• in the bone marrow

increased granulocyte number ( J:205633 )

decreased B cell number ( J:205633 )

• in the bone marrow

increased NK T cell number ( J:205633 )

• 1.7-fold in CD3+ T cells