Phenotypes associated with this allele

• Allele Symbol: Cr2^tm2.1Jhws
• Allele Name: targeted mutation 2.1, John Weiss
• Allele ID: MGI:5547397
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cr2^tm2.1Jhws/Cr2^tm2.1Jhws	B6.129-Cr2^tm2.1Jhws	MGI:5547493

Genotype
MGI:5547493

hm1

• Allelic Composition: Cr2^tm2.1Jhws/Cr2^tm2.1Jhws
• Genetic Background: B6.129-Cr2^tm2.1Jhws

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:205353 )

N • mice exhibit normal survival in response to S. pneumonia infection

immune system

immune system phenotype ( J:205353 )

N • mice exhibit normal B cell subsets and basal serum imunoglobulin levels

N • mice exhibit normal IgG1, IgG2b and IgG2c response to TNP-LPS, DNP-Ficoll or TNP-KLH (10ug or 100ug)

N • mice exhibit normal survival in response to S. pneumonia infection

abnormal germinal center B cell physiology ( J:205353 )

• failure to produce activated germinal center B cells after sheep red blood cell immunization unlike wild-type mice

decreased IgG3 level ( J:205353 )

• in response to TNP-KLH (100ug)

• however, levels are normal in response to TNP-LPS, DNP-Ficoll or 10ug TNP-KLH

decreased IgM level ( J:205353 )

• in response to DNP-Ficoll or TNP-KLH (100ug)

• however, levels are normal in response to 10ug TNP-KLH

increased IgM level ( J:205353 )

• in response to TNP-LPS or DNP-Ficoll

hematopoietic system

abnormal germinal center B cell physiology ( J:205353 )

• failure to produce activated germinal center B cells after sheep red blood cell immunization unlike wild-type mice

decreased IgG3 level ( J:205353 )

• in response to TNP-KLH (100ug)

• however, levels are normal in response to TNP-LPS, DNP-Ficoll or 10ug TNP-KLH

decreased IgM level ( J:205353 )

• in response to DNP-Ficoll or TNP-KLH (100ug)

• however, levels are normal in response to 10ug TNP-KLH

increased IgM level ( J:205353 )

• in response to TNP-LPS or DNP-Ficoll